(9 nodes) (2017) Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction. network (Oryctolagus cuniculus)

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Your Input:
	G6PC3	Glucose-6-phosphatase catalytic subunit 3. (562 aa)
	PPP1R3A	Protein phosphatase 1 regulatory subunit 3A; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). (1109 aa)
	G6PC2	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
	IRS1	Insulin receptor substrate 1. (1220 aa)
	FOXO1	Fork-head domain-containing protein. (613 aa)
	G6PC	Glucose-6-phosphatase catalytic subunit. (359 aa)
	GCG	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity). (180 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
	LOC100339305	Uncharacterized protein. (506 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FOXO1	G6PC	ENSOCUP00000012389	ENSOCUP00000013761	Fork-head domain-containing protein.	Glucose-6-phosphatase catalytic subunit.	0.856
FOXO1	G6PC2	ENSOCUP00000012389	ENSOCUP00000001179	Fork-head domain-containing protein.	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.790
FOXO1	G6PC3	ENSOCUP00000012389	ENSOCUP00000033043	Fork-head domain-containing protein.	Glucose-6-phosphatase catalytic subunit 3.	0.785
FOXO1	GCG	ENSOCUP00000012389	ENSOCUP00000019727	Fork-head domain-containing protein.	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	0.709
FOXO1	INS	ENSOCUP00000012389	ENSOCUP00000020463	Fork-head domain-containing protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.878
FOXO1	IRS1	ENSOCUP00000012389	ENSOCUP00000006209	Fork-head domain-containing protein.	Insulin receptor substrate 1.	0.812
FOXO1	LOC100339305	ENSOCUP00000012389	ENSOCUP00000030706	Fork-head domain-containing protein.	Uncharacterized protein.	0.677
G6PC	FOXO1	ENSOCUP00000013761	ENSOCUP00000012389	Glucose-6-phosphatase catalytic subunit.	Fork-head domain-containing protein.	0.856
G6PC	G6PC2	ENSOCUP00000013761	ENSOCUP00000001179	Glucose-6-phosphatase catalytic subunit.	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.939
G6PC	G6PC3	ENSOCUP00000013761	ENSOCUP00000033043	Glucose-6-phosphatase catalytic subunit.	Glucose-6-phosphatase catalytic subunit 3.	0.910
G6PC	GCG	ENSOCUP00000013761	ENSOCUP00000019727	Glucose-6-phosphatase catalytic subunit.	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	0.761
G6PC	INS	ENSOCUP00000013761	ENSOCUP00000020463	Glucose-6-phosphatase catalytic subunit.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.817
G6PC	IRS1	ENSOCUP00000013761	ENSOCUP00000006209	Glucose-6-phosphatase catalytic subunit.	Insulin receptor substrate 1.	0.729
G6PC	LOC100339305	ENSOCUP00000013761	ENSOCUP00000030706	Glucose-6-phosphatase catalytic subunit.	Uncharacterized protein.	0.578
G6PC2	FOXO1	ENSOCUP00000001179	ENSOCUP00000012389	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Fork-head domain-containing protein.	0.790
G6PC2	G6PC	ENSOCUP00000001179	ENSOCUP00000013761	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Glucose-6-phosphatase catalytic subunit.	0.939
G6PC2	G6PC3	ENSOCUP00000001179	ENSOCUP00000033043	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Glucose-6-phosphatase catalytic subunit 3.	0.908
G6PC2	GCG	ENSOCUP00000001179	ENSOCUP00000019727	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	0.743
G6PC2	INS	ENSOCUP00000001179	ENSOCUP00000020463	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.782
G6PC2	IRS1	ENSOCUP00000001179	ENSOCUP00000006209	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Insulin receptor substrate 1.	0.687