STRINGSTRING
LOC100344410 LOC100344410 FLT3 FLT3 PREB PREB EBF1 EBF1 IL7R IL7R PAX5 PAX5 RUNX1 RUNX1 LOC100357927 LOC100357927 H3F3B H3F3B EPOR EPOR ETV6 ETV6 LIN28B LIN28B H3C13 H3C13 LOC100345683 LOC100345683 IGHM-2 IGHM-2 H3-3A H3-3A RAG1 RAG1 RAG2 RAG2 G1TX56_RABIT G1TX56_RABIT CEBPA CEBPA NANOG NANOG AICDA AICDA STAT5A STAT5A GATA1 GATA1 IGHM-3 IGHM-3 G1TJR7_RABIT G1TJR7_RABIT FURIN FURIN CSF2RA CSF2RA CSF3R CSF3R CD34 CD34 KITLG KITLG CSF1R CSF1R KIT KIT CD19 CD19 IL3RA IL3RA CD38 CD38 MME MME ENSOCUP00000042583 ENSOCUP00000042583 MPO MPO GAPDH GAPDH CD8A CD8A DNTT DNTT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100344410Histone domain-containing protein. (136 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
PREBProlactin regulatory element binding. (418 aa)
EBF1EBF transcription factor 1. (591 aa)
IL7RInterleukin 7 receptor. (458 aa)
PAX5Paired box 5. (371 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (466 aa)
LOC100357927Histone domain-containing protein. (136 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
EPORErythropoietin receptor. (554 aa)
ETV6ETS variant 6. (508 aa)
LIN28BLin-28 homolog B. (258 aa)
H3C13Histone H3; Belongs to the histone H3 family. (136 aa)
LOC100345683Histone H3; Belongs to the histone H3 family. (136 aa)
IGHM-2Ig-like domain-containing protein. (167 aa)
H3-3AHistone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
RAG2V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (527 aa)
G1TX56_RABITHistone H3; Belongs to the histone H3 family. (136 aa)
CEBPACCAAT enhancer binding protein alpha. (402 aa)
NANOGHomeobox domain-containing protein. (306 aa)
AICDAActivation induced cytidine deaminase. (198 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
GATA1GATA binding protein 1. (413 aa)
IGHM-3Ig-like domain-containing protein. (167 aa)
G1TJR7_RABITHistone H3; Belongs to the histone H3 family. (136 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (666 aa)
CSF2RAFibronectin type-III domain-containing protein. (443 aa)
CSF3RColony stimulating factor 3 receptor. (1027 aa)
CD34CD34 molecule. (415 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (276 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
CD19CD19 molecule. (573 aa)
IL3RAUncharacterized protein. (394 aa)
CD38ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. (299 aa)
MMENeprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. (750 aa)
ENSOCUP00000042583Histone H3; Belongs to the histone H3 family. (115 aa)
MPOMyeloperoxidase. (725 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
CD8AIg-like domain-containing protein. (394 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (569 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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