STRINGSTRING
EZH1 EZH1 PRDM1 PRDM1 BCR BCR GATA1 GATA1 CD5 CD5 ASXL1 ASXL1 RAG1 RAG1 IL10 IL10 LDB1 LDB1 HOXB5 HOXB5 GATA3 GATA3 TCF12 TCF12 B2M B2M CD93 CD93 HDAC9 HDAC9 IKZF1 IKZF1 FOXO1 FOXO1 CD48 CD48 SMARCA5 SMARCA5 PAX5 PAX5 RUNX2 RUNX2 FOXP3 FOXP3 IL2 IL2 CD69 CD69 EBF1 EBF1 FOXP1 FOXP1 NFATC1 NFATC1 LMO2 LMO2 BCL11A BCL11A CD44 CD44 ACTB ACTB GAPDH GAPDH CBX8 CBX8 IFNG IFNG IL7 IL7 CD19 CD19 KIT KIT CD4 CD4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (834 aa)
PRDM1PR/SET domain 1. (889 aa)
BCRBCR activator of RhoGEF and GTPase. (1192 aa)
GATA1GATA binding protein 1. (413 aa)
CD5Uncharacterized protein. (488 aa)
ASXL1ASXL transcriptional regulator 1. (1512 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
LDB1LIM domain binding 1. (410 aa)
HOXB5Homeobox B5. (269 aa)
GATA3GATA binding protein 3. (444 aa)
TCF12Transcription factor 12. (675 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (120 aa)
CD93CD93 molecule. (653 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1068 aa)
IKZF1IKAROS family zinc finger 1. (515 aa)
FOXO1Fork-head domain-containing protein. (613 aa)
CD48Ig-like domain-containing protein. (291 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1051 aa)
PAX5Paired box 5. (371 aa)
RUNX2RUNX family transcription factor 2. (343 aa)
FOXP3Forkhead box P3. (455 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (153 aa)
CD69CD69 molecule. (201 aa)
EBF1EBF transcription factor 1. (591 aa)
FOXP1Fork-head domain-containing protein. (714 aa)
NFATC1RHD domain-containing protein. (672 aa)
LMO2LIM domain only 2. (158 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (975 aa)
CD44CD44 molecule (Indian blood group). (761 aa)
ACTBUncharacterized protein. (357 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
CBX8Chromobox 8. (434 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (198 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
CD19CD19 molecule. (573 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (20%) [HD]