STRINGSTRING
EZH2 EZH2 KLF6 KLF6 NOG NOG NR4A2 NR4A2 JUN JUN IL7 IL7 CD19 CD19 CTCF CTCF KIT KIT E2F2 E2F2 CD79B CD79B CD34 CD34 SMARCA4 SMARCA4 CD4 CD4 TEAD1 TEAD1 CSF2RA CSF2RA IGHM-3 IGHM-3 VPREB1-2 VPREB1-2 DNMT3A DNMT3A NANOG NANOG FOS FOS RAG1 RAG1 INS INS CHD4 CHD4 CCNA2 CCNA2 IGHM-2 IGHM-2 SPIB SPIB VPREB1 VPREB1 CEBPB CEBPB IGLL1 IGLL1 POU5F1 POU5F1 HHEX HHEX EPOR EPOR FOXO1 FOXO1 EGR2 EGR2 PAX5 PAX5 NR4A1 NR4A1 MYB MYB FOSL2 FOSL2 LMNA LMNA KLF7 KLF7 IRF4 IRF4 EBF1 EBF1 TEAD2 TEAD2 EGR1 EGR1 KLF4 KLF4 BMI1 BMI1 FLT3 FLT3 ESR1 ESR1 BACH2 BACH2 TEAD4 TEAD4 CSF2 CSF2 CDK1 CDK1 SUZ12 SUZ12 IKZF3 IKZF3 BCL11A BCL11A IRF8 IRF8 NFIL3 NFIL3 DLL1 DLL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (769 aa)
KLF6Kruppel like factor 6. (317 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (609 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
CD19CD19 molecule. (573 aa)
CTCFCCCTC-binding factor. (738 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
E2F2E2F transcription factor 2. (440 aa)
CD79BCD79b molecule. (282 aa)
CD34CD34 molecule. (415 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1653 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
TEAD1TEA domain transcription factor 1. (493 aa)
CSF2RAFibronectin type-III domain-containing protein. (443 aa)
IGHM-3Ig-like domain-containing protein. (167 aa)
VPREB1-2Ig-like domain-containing protein. (147 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (843 aa)
NANOGHomeobox domain-containing protein. (306 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
CHD4Uncharacterized protein. (1940 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (424 aa)
IGHM-2Ig-like domain-containing protein. (167 aa)
SPIBETS domain-containing protein. (158 aa)
VPREB1Ig-like domain-containing protein. (147 aa)
CEBPBCCAAT enhancer binding protein beta. (353 aa)
IGLL1Lambda5. (208 aa)
POU5F1POU domain protein. (360 aa)
HHEXHomeobox domain-containing protein. (269 aa)
EPORErythropoietin receptor. (554 aa)
FOXO1Fork-head domain-containing protein. (613 aa)
EGR2Early growth response 2. (549 aa)
PAX5Paired box 5. (371 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (784 aa)
MYBMYB proto-oncogene, transcription factor. (758 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (704 aa)
KLF7Kruppel like factor 7. (302 aa)
IRF4Interferon regulatory factor 4. (451 aa)
EBF1EBF transcription factor 1. (591 aa)
TEAD2TEA domain transcription factor 2. (405 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (700 aa)
KLF4Uncharacterized protein. (145 aa)
BMI1RING-type domain-containing protein. (326 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
BACH2BTB domain and CNC homolog 2. (774 aa)
TEAD4Tetraspanin. (541 aa)
CSF2Uncharacterized protein. (144 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (741 aa)
IKZF3IKAROS family zinc finger 3. (509 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (975 aa)
IRF8Interferon regulatory factor 8. (455 aa)
NFIL3Nuclear factor, interleukin 3 regulated. (466 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (754 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.