STRINGSTRING
EBF2 EBF2 PDGFRB PDGFRB GFI1B GFI1B IRF7 IRF7 FLT3 FLT3 KLF4 KLF4 HLX HLX TET2 TET2 THY1 THY1 EBF1 EBF1 IRF4 IRF4 FOXP3 FOXP3 STAT3 STAT3 PAX5 PAX5 RUNX1 RUNX1 FOXO1 FOXO1 POU5F1 POU5F1 GATA3 GATA3 IGLL1 IGLL1 CEBPB CEBPB VPREB1 VPREB1 RAG1 RAG1 ID2 ID2 TET3 TET3 VPREB1-2 VPREB1-2 GATA1 GATA1 CSF1 CSF1 CD4 CD4 KIT KIT CTCF CTCF CD19 CD19 IL7 IL7 ESRRB ESRRB GAPDH GAPDH NEUROD1 NEUROD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EBF2EBF transcription factor 2. (609 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
GFI1BGrowth factor independent 1B transcriptional repressor. (395 aa)
IRF7Interferon regulatory factor 7. (438 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
KLF4Uncharacterized protein. (145 aa)
HLXH2.0 like homeobox. (682 aa)
TET2Tet methylcytosine dioxygenase 2. (2011 aa)
THY1Thy-1 cell surface antigen. (161 aa)
EBF1EBF transcription factor 1. (591 aa)
IRF4Interferon regulatory factor 4. (451 aa)
FOXP3Forkhead box P3. (455 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PAX5Paired box 5. (371 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (466 aa)
FOXO1Fork-head domain-containing protein. (613 aa)
POU5F1POU domain protein. (360 aa)
GATA3GATA binding protein 3. (444 aa)
IGLL1Lambda5. (208 aa)
CEBPBCCAAT enhancer binding protein beta. (353 aa)
VPREB1Ig-like domain-containing protein. (147 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
ID2Inhibitor of DNA binding 2. (109 aa)
TET3Tet methylcytosine dioxygenase 3. (1777 aa)
VPREB1-2Ig-like domain-containing protein. (147 aa)
GATA1GATA binding protein 1. (413 aa)
CSF1Colony stimulating factor 1. (535 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
CTCFCCCTC-binding factor. (738 aa)
CD19CD19 molecule. (573 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
ESRRBEstrogen related receptor beta. (454 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
NEUROD1BHLH domain-containing protein. (203 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.