STRINGSTRING
CUL1 CUL1 DDB2 DDB2 DDB1 DDB1 CUL7 CUL7 GAPDH GAPDH CUL4B CUL4B STAT1 STAT1 CUL3 CUL3 PIK3C3 PIK3C3 SMUG1 SMUG1 SKP1 SKP1 CDT1 CDT1 CUL2 CUL2 CUL5 CUL5 DCAF1 DCAF1 CUL4A CUL4A DCAF13 DCAF13 PTEN PTEN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
CUL7Cullin 7; Belongs to the cullin family. (1728 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
CUL4BCullin 4B; Belongs to the cullin family. (901 aa)
STAT1Signal transducer and activator of transcription. (879 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (899 aa)
SMUG1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (277 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
CDT1Chromatin licensing and DNA replication factor 1. (365 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1507 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
DCAF13DDB1 and CUL4 associated factor 13. (596 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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