(6 nodes) (2018) Differential alpha-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity. network (Oryctolagus cuniculus)

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Your Input:
	SNCA	Alpha-synuclein; Belongs to the synuclein family. (172 aa)
	TLR2	TIR domain-containing protein; Belongs to the Toll-like receptor family. (784 aa)
	GPX1	Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (200 aa)
	CA12	Carbonic anhydrase 12; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family. (372 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (515 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (346 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	GFAP	ENSOCUP00000036614	ENSOCUP00000034730	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.927
CASP3	GPX1	ENSOCUP00000036614	ENSOCUP00000005141	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown.	0.793
CASP3	SNCA	ENSOCUP00000036614	ENSOCUP00000039624	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Alpha-synuclein; Belongs to the synuclein family.	0.743
CASP3	TLR2	ENSOCUP00000036614	ENSOCUP00000002918	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.632
GFAP	CASP3	ENSOCUP00000034730	ENSOCUP00000036614	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.927
GFAP	SNCA	ENSOCUP00000034730	ENSOCUP00000039624	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Alpha-synuclein; Belongs to the synuclein family.	0.757
GFAP	TLR2	ENSOCUP00000034730	ENSOCUP00000002918	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.492
GPX1	CASP3	ENSOCUP00000005141	ENSOCUP00000036614	Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.793
GPX1	SNCA	ENSOCUP00000005141	ENSOCUP00000039624	Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown.	Alpha-synuclein; Belongs to the synuclein family.	0.488
SNCA	CASP3	ENSOCUP00000039624	ENSOCUP00000036614	Alpha-synuclein; Belongs to the synuclein family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.743
SNCA	GFAP	ENSOCUP00000039624	ENSOCUP00000034730	Alpha-synuclein; Belongs to the synuclein family.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.757
SNCA	GPX1	ENSOCUP00000039624	ENSOCUP00000005141	Alpha-synuclein; Belongs to the synuclein family.	Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown.	0.488
SNCA	TLR2	ENSOCUP00000039624	ENSOCUP00000002918	Alpha-synuclein; Belongs to the synuclein family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.627
TLR2	CASP3	ENSOCUP00000002918	ENSOCUP00000036614	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.632
TLR2	GFAP	ENSOCUP00000002918	ENSOCUP00000034730	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.492
TLR2	SNCA	ENSOCUP00000002918	ENSOCUP00000039624	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Alpha-synuclein; Belongs to the synuclein family.	0.627