13 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	SKP2	F-box domain-containing protein. (435 aa)
	NAE1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (537 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (775 aa)
	NEDD8	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
	PXDNL	Peroxidasin like. (1467 aa)
	KLHL20	BTB domain-containing protein. (609 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
	BECN1	Uncharacterized protein. (448 aa)
	UBE2M	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa)
	RARA	Retinoic acid receptor alpha. (462 aa)
	PXDN	Peroxidasin. (1411 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (771 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (498 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BECN1	CUL3	ENSOCUP00000013727	ENSOCUP00000031324	Uncharacterized protein.	Cullin 3; Belongs to the cullin family.	0.409
BECN1	MTOR	ENSOCUP00000013727	ENSOCUP00000011253	Uncharacterized protein.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.808
BECN1	PXDN	ENSOCUP00000013727	ENSOCUP00000022906	Uncharacterized protein.	Peroxidasin.	0.839
BECN1	PXDNL	ENSOCUP00000013727	ENSOCUP00000004823	Uncharacterized protein.	Peroxidasin like.	0.839
BECN1	SKP2	ENSOCUP00000013727	ENSOCUP00000007901	Uncharacterized protein.	F-box domain-containing protein.	0.546
CUL1	CUL3	ENSOCUP00000002198	ENSOCUP00000031324	Cullin 1; Belongs to the cullin family.	Cullin 3; Belongs to the cullin family.	0.887
CUL1	KLHL20	ENSOCUP00000002198	ENSOCUP00000008064	Cullin 1; Belongs to the cullin family.	BTB domain-containing protein.	0.671
CUL1	NAE1	ENSOCUP00000002198	ENSOCUP00000000498	Cullin 1; Belongs to the cullin family.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.904
CUL1	NEDD8	ENSOCUP00000002198	ENSOCUP00000002526	Cullin 1; Belongs to the cullin family.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.999
CUL1	PXDN	ENSOCUP00000002198	ENSOCUP00000022906	Cullin 1; Belongs to the cullin family.	Peroxidasin.	0.459
CUL1	PXDNL	ENSOCUP00000002198	ENSOCUP00000004823	Cullin 1; Belongs to the cullin family.	Peroxidasin like.	0.455
CUL1	SKP2	ENSOCUP00000002198	ENSOCUP00000007901	Cullin 1; Belongs to the cullin family.	F-box domain-containing protein.	0.999
CUL1	UBE2M	ENSOCUP00000002198	ENSOCUP00000014290	Cullin 1; Belongs to the cullin family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.979
CUL3	BECN1	ENSOCUP00000031324	ENSOCUP00000013727	Cullin 3; Belongs to the cullin family.	Uncharacterized protein.	0.409
CUL3	CUL1	ENSOCUP00000031324	ENSOCUP00000002198	Cullin 3; Belongs to the cullin family.	Cullin 1; Belongs to the cullin family.	0.887
CUL3	KLHL20	ENSOCUP00000031324	ENSOCUP00000008064	Cullin 3; Belongs to the cullin family.	BTB domain-containing protein.	0.996
CUL3	NAE1	ENSOCUP00000031324	ENSOCUP00000000498	Cullin 3; Belongs to the cullin family.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.864
CUL3	NEDD8	ENSOCUP00000031324	ENSOCUP00000002526	Cullin 3; Belongs to the cullin family.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.995
CUL3	PXDN	ENSOCUP00000031324	ENSOCUP00000022906	Cullin 3; Belongs to the cullin family.	Peroxidasin.	0.436
CUL3	PXDNL	ENSOCUP00000031324	ENSOCUP00000004823	Cullin 3; Belongs to the cullin family.	Peroxidasin like.	0.436