21 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	SUMO2	Small ubiquitin-related modifier. (95 aa)
	PARK2	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (394 aa)
	G1TUX3_RABIT	Rad60-SLD domain-containing protein. (66 aa)
	CDT1	Chromatin licensing and DNA replication factor 1. (365 aa)
	UBE2M	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (745 aa)
	CUL5	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (759 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (463 aa)
	PINK1	PTEN induced kinase 1. (569 aa)
	WT1	WT1 transcription factor. (302 aa)
	NEDD8	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (775 aa)
	NAE1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (537 aa)
	KEAP1	Kelch like ECH associated protein 1. (631 aa)
	UBE2F	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (220 aa)
	SUMO2-2	Rad60-SLD domain-containing protein. (71 aa)
	USP5	Ubiquitinyl hydrolase 1. (936 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (771 aa)
	JUN	BZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (901 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDT1	CUL1	ENSOCUP00000015721	ENSOCUP00000002198	Chromatin licensing and DNA replication factor 1.	Cullin 1; Belongs to the cullin family.	0.800
CDT1	CUL2	ENSOCUP00000015721	ENSOCUP00000012675	Chromatin licensing and DNA replication factor 1.	Cullin 2; Belongs to the cullin family.	0.572
CDT1	CUL3	ENSOCUP00000015721	ENSOCUP00000031324	Chromatin licensing and DNA replication factor 1.	Cullin 3; Belongs to the cullin family.	0.622
CDT1	CUL4A	ENSOCUP00000015721	ENSOCUP00000008283	Chromatin licensing and DNA replication factor 1.	Cullin 4A; Belongs to the cullin family.	0.909
CDT1	CUL4B	ENSOCUP00000015721	ENSOCUP00000040452	Chromatin licensing and DNA replication factor 1.	Cullin 4B; Belongs to the cullin family.	0.884
CDT1	CUL5	ENSOCUP00000015721	ENSOCUP00000009389	Chromatin licensing and DNA replication factor 1.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.552
CDT1	NAE1	ENSOCUP00000015721	ENSOCUP00000000498	Chromatin licensing and DNA replication factor 1.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.455
CDT1	NEDD8	ENSOCUP00000015721	ENSOCUP00000002526	Chromatin licensing and DNA replication factor 1.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.844
CDT1	UBA3	ENSOCUP00000015721	ENSOCUP00000007065	Chromatin licensing and DNA replication factor 1.	Ubiquitin like modifier activating enzyme 3.	0.419
CUL1	CDT1	ENSOCUP00000002198	ENSOCUP00000015721	Cullin 1; Belongs to the cullin family.	Chromatin licensing and DNA replication factor 1.	0.800
CUL1	CUL2	ENSOCUP00000002198	ENSOCUP00000012675	Cullin 1; Belongs to the cullin family.	Cullin 2; Belongs to the cullin family.	0.742
CUL1	CUL3	ENSOCUP00000002198	ENSOCUP00000031324	Cullin 1; Belongs to the cullin family.	Cullin 3; Belongs to the cullin family.	0.887
CUL1	CUL4A	ENSOCUP00000002198	ENSOCUP00000008283	Cullin 1; Belongs to the cullin family.	Cullin 4A; Belongs to the cullin family.	0.903
CUL1	CUL4B	ENSOCUP00000002198	ENSOCUP00000040452	Cullin 1; Belongs to the cullin family.	Cullin 4B; Belongs to the cullin family.	0.845
CUL1	CUL5	ENSOCUP00000002198	ENSOCUP00000009389	Cullin 1; Belongs to the cullin family.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.865
CUL1	JUN	ENSOCUP00000002198	ENSOCUP00000040325	Cullin 1; Belongs to the cullin family.	BZIP domain-containing protein; Belongs to the bZIP family.	0.575
CUL1	KEAP1	ENSOCUP00000002198	ENSOCUP00000044015	Cullin 1; Belongs to the cullin family.	Kelch like ECH associated protein 1.	0.858
CUL1	NAE1	ENSOCUP00000002198	ENSOCUP00000000498	Cullin 1; Belongs to the cullin family.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.904
CUL1	NEDD8	ENSOCUP00000002198	ENSOCUP00000002526	Cullin 1; Belongs to the cullin family.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.999
CUL1	PARK2	ENSOCUP00000002198	ENSOCUP00000022026	Cullin 1; Belongs to the cullin family.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.426