node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD1 | MYL2 | ENSOCUP00000005966 | ENSOCUP00000028408 | Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.542 |
ESR1 | PRKACB | ENSOCUP00000004174 | ENSOCUP00000043583 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.957 |
G1TPW3_RABIT | ODC1 | ENSOCUP00000019051 | ENSOCUP00000004258 | Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.903 |
LMOD2 | MYL2 | ENSOCUP00000030857 | ENSOCUP00000028408 | Leiomodin 2. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.635 |
LMOD2 | NEB | ENSOCUP00000030857 | ENSOCUP00000048133 | Leiomodin 2. | Nebulin. | 0.861 |
LMOD2 | TNNT2 | ENSOCUP00000030857 | ENSOCUP00000018870 | Leiomodin 2. | Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.573 |
MYL2 | ANKRD1 | ENSOCUP00000028408 | ENSOCUP00000005966 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). | 0.542 |
MYL2 | LMOD2 | ENSOCUP00000028408 | ENSOCUP00000030857 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | Leiomodin 2. | 0.635 |
MYL2 | NEB | ENSOCUP00000028408 | ENSOCUP00000048133 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | Nebulin. | 0.699 |
MYL2 | TMOD1 | ENSOCUP00000028408 | ENSOCUP00000011899 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | Tropomodulin 1. | 0.498 |
MYL2 | TNNT2 | ENSOCUP00000028408 | ENSOCUP00000018870 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.933 |
NEB | LMOD2 | ENSOCUP00000048133 | ENSOCUP00000030857 | Nebulin. | Leiomodin 2. | 0.861 |
NEB | MYL2 | ENSOCUP00000048133 | ENSOCUP00000028408 | Nebulin. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.699 |
NEB | TMOD1 | ENSOCUP00000048133 | ENSOCUP00000011899 | Nebulin. | Tropomodulin 1. | 0.919 |
NEB | TNNT2 | ENSOCUP00000048133 | ENSOCUP00000018870 | Nebulin. | Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.533 |
ODC1 | G1TPW3_RABIT | ENSOCUP00000004258 | ENSOCUP00000019051 | Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.903 |
PRKACB | ESR1 | ENSOCUP00000043583 | ENSOCUP00000004174 | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.957 |
TMOD1 | MYL2 | ENSOCUP00000011899 | ENSOCUP00000028408 | Tropomodulin 1. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.498 |
TMOD1 | NEB | ENSOCUP00000011899 | ENSOCUP00000048133 | Tropomodulin 1. | Nebulin. | 0.919 |
TMOD1 | TNNT2 | ENSOCUP00000011899 | ENSOCUP00000018870 | Tropomodulin 1. | Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.522 |