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GLB1 GLB1 LOC103345097 LOC103345097 GLB1L2 GLB1L2 CUL4B CUL4B UBE2G2 UBE2G2 CRBN CRBN CUL3 CUL3 LOC100354960 LOC100354960 UBE2D2 UBE2D2 UBE2G1 UBE2G1 SKP1 SKP1 CDC34 CDC34 RBM39 RBM39 CDT1 CDT1 UBE2M UBE2M CUL2 CUL2 IKZF1 IKZF1 MYC MYC GLB1L3 GLB1L3 ARIH1 ARIH1 CUL5 CUL5 ELOB ELOB CUL4A CUL4A UBA1 UBA1 ZFP91 ZFP91 NEDD8 NEDD8 CUL1 CUL1 DDB1 DDB1 CUL7 CUL7 IKZF3 IKZF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLB1Beta-galactosidase. (843 aa)
LOC103345097Beta-galactosidase. (683 aa)
GLB1L2Beta-galactosidase. (699 aa)
CUL4BCullin 4B; Belongs to the cullin family. (901 aa)
UBE2G2Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (198 aa)
CRBNCereblon. (491 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
LOC100354960UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (305 aa)
UBE2D2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (317 aa)
UBE2G1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
CDC34Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (227 aa)
RBM39RNA binding motif protein 39 isoform a (Predicted). (530 aa)
CDT1Chromatin licensing and DNA replication factor 1. (365 aa)
UBE2MUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
IKZF1IKAROS family zinc finger 1. (515 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
GLB1L3Beta-galactosidase. (654 aa)
ARIH1RBR-type E3 ubiquitin transferase. (500 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
ELOBElongin B. (118 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
UBA1Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity). (1058 aa)
ZFP91Uncharacterized protein. (482 aa)
NEDD8NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
CUL7Cullin 7; Belongs to the cullin family. (1728 aa)
IKZF3IKAROS family zinc finger 3. (509 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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