STRINGSTRING
PDGFRA PDGFRA IL7R IL7R MYB MYB PAX5 PAX5 PTGER2 PTGER2 CCND2 CCND2 VAPB VAPB SYK SYK IGLL1 IGLL1 ANXA1 ANXA1 IL6 IL6 P4HA2 P4HA2 IGHM-2 IGHM-2 CD63 CD63 RAG1 RAG1 RAG2 RAG2 TYROBP TYROBP MAFB MAFB CD5 CD5 IGHM-3 IGHM-3 BCR BCR PRDM1 PRDM1 CD247 CD247 CD72 CD72 NFATC4 NFATC4 CD4 CD4 CD79B CD79B RALY RALY MYD88 MYD88 MGLL MGLL IL6R IL6R ITM2B ITM2B CD19 CD19 CCND3 CCND3 IGF2R IGF2R CD38 CD38 CD3D CD3D CD22 CD22 MME MME SRC SRC CD6 CD6 BCL6 BCL6 BTK BTK ALK ALK P4HA1 P4HA1 SP3 SP3 HCK HCK IRF4 IRF4 CD27 CD27 XBP1 XBP1 ZAP70 ZAP70 NSD2 NSD2 CCR2 CCR2 CCR1 CCR1 ENO2 ENO2 CD83 CD83 CASP2 CASP2 CXCR4 CXCR4 PLTP PLTP CD3G CD3G
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFRAProtein kinase domain-containing protein. (773 aa)
IL7RInterleukin 7 receptor. (458 aa)
MYBMYB proto-oncogene, transcription factor. (758 aa)
PAX5Paired box 5. (371 aa)
PTGER2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (361 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (431 aa)
VAPBVAMP associated protein B and C. (259 aa)
SYKTyrosine-protein kinase. (630 aa)
IGLL1Lambda5. (208 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (334 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
P4HA2Prolyl 4-hydroxylase subunit alpha 2. (544 aa)
IGHM-2Ig-like domain-containing protein. (167 aa)
CD63CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] (411 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
RAG2V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (527 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (110 aa)
MAFBMAF bZIP transcription factor B. (307 aa)
CD5Uncharacterized protein. (488 aa)
IGHM-3Ig-like domain-containing protein. (167 aa)
BCRBCR activator of RhoGEF and GTPase. (1192 aa)
PRDM1PR/SET domain 1. (889 aa)
CD247T-cell surface glycoprotein CD3 zeta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of d [...] (239 aa)
CD72C-type lectin domain-containing protein. (410 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
CD79BCD79b molecule. (282 aa)
RALYRALY heterogeneous nuclear ribonucleoprotein. (370 aa)
MYD88Uncharacterized protein. (476 aa)
MGLLUncharacterized protein. (190 aa)
IL6RInterleukin 6 receptor. (569 aa)
ITM2BIntegral membrane protein 2B. (294 aa)
CD19CD19 molecule. (573 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (287 aa)
IGF2RInsulin like growth factor 2 receptor. (2697 aa)
CD38ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. (299 aa)
CD3DIg_4 domain-containing protein. (177 aa)
CD22CD22 molecule. (966 aa)
MMENeprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. (750 aa)
SRCTyrosine-protein kinase. (589 aa)
CD6CD6 molecule. (683 aa)
BCL6BCL6 transcription repressor. (723 aa)
BTKTyrosine-protein kinase. (659 aa)
ALKTyrosine-protein kinase receptor. (1448 aa)
P4HA1Prolyl 4-hydroxylase subunit alpha 1. (534 aa)
SP3Sp3 transcription factor. (715 aa)
HCKTyrosine-protein kinase. (525 aa)
IRF4Interferon regulatory factor 4. (451 aa)
CD27CD27 molecule. (260 aa)
XBP1X-box binding protein 1. (208 aa)
ZAP70Tyrosine-protein kinase. (623 aa)
NSD2Uncharacterized protein. (475 aa)
CCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CCR1Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (351 aa)
ENO2Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family. (434 aa)
CD83CD83 molecule. (292 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (451 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (366 aa)
PLTPPhospholipid transfer protein. (636 aa)
CD3GIGc2 domain-containing protein. (182 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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