(18 nodes) (2018) Hypothalamic PDE3B deficiency alters body weight and glucose homeostasis in mouse network (Oryctolagus cuniculus)

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Your Input:
	POMC	NPP domain-containing protein. (285 aa)
	G6PC3	Glucose-6-phosphatase catalytic subunit 3. (562 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (899 aa)
	PXDN	Peroxidasin. (1411 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	LEPR	Leptin receptor. (1164 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	G6PC2	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
	UCP1	Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra [...] (297 aa)
	PXDNL	Peroxidasin like. (1467 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (461 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	NPY	Neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. (97 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	AGRP	Agouti related neuropeptide. (132 aa)
	FOXO1	Fork-head domain-containing protein. (613 aa)
	G6PC	Glucose-6-phosphatase catalytic subunit. (359 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRP	FOXO1	ENSOCUP00000010187	ENSOCUP00000012389	Agouti related neuropeptide.	Fork-head domain-containing protein.	0.752
AGRP	INS	ENSOCUP00000010187	ENSOCUP00000020463	Agouti related neuropeptide.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.823
AGRP	JAK2	ENSOCUP00000010187	ENSOCUP00000014491	Agouti related neuropeptide.	Tyrosine-protein kinase.	0.439
AGRP	LEP	ENSOCUP00000010187	ENSOCUP00000008782	Agouti related neuropeptide.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.942
AGRP	LEPR	ENSOCUP00000010187	ENSOCUP00000014912	Agouti related neuropeptide.	Leptin receptor.	0.858
AGRP	NPY	ENSOCUP00000010187	ENSOCUP00000009261	Agouti related neuropeptide.	Neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.	0.985
AGRP	NR5A1	ENSOCUP00000010187	ENSOCUP00000006784	Agouti related neuropeptide.	Nuclear receptor subfamily 5 group A member 1.	0.649
AGRP	POMC	ENSOCUP00000010187	ENSOCUP00000037970	Agouti related neuropeptide.	NPP domain-containing protein.	0.986
AGRP	STAT3	ENSOCUP00000010187	ENSOCUP00000009494	Agouti related neuropeptide.	Signal transducer and activator of transcription.	0.668
AGRP	UCP1	ENSOCUP00000010187	ENSOCUP00000001977	Agouti related neuropeptide.	Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra [...]	0.700
FOXO1	AGRP	ENSOCUP00000012389	ENSOCUP00000010187	Fork-head domain-containing protein.	Agouti related neuropeptide.	0.752
FOXO1	G6PC	ENSOCUP00000012389	ENSOCUP00000013761	Fork-head domain-containing protein.	Glucose-6-phosphatase catalytic subunit.	0.856
FOXO1	G6PC2	ENSOCUP00000012389	ENSOCUP00000001179	Fork-head domain-containing protein.	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.790
FOXO1	G6PC3	ENSOCUP00000012389	ENSOCUP00000033043	Fork-head domain-containing protein.	Glucose-6-phosphatase catalytic subunit 3.	0.785
FOXO1	INS	ENSOCUP00000012389	ENSOCUP00000020463	Fork-head domain-containing protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.878
FOXO1	JAK2	ENSOCUP00000012389	ENSOCUP00000014491	Fork-head domain-containing protein.	Tyrosine-protein kinase.	0.462
FOXO1	LEP	ENSOCUP00000012389	ENSOCUP00000008782	Fork-head domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.632
FOXO1	LEPR	ENSOCUP00000012389	ENSOCUP00000014912	Fork-head domain-containing protein.	Leptin receptor.	0.424
FOXO1	NPY	ENSOCUP00000012389	ENSOCUP00000009261	Fork-head domain-containing protein.	Neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.	0.576
FOXO1	PCK1	ENSOCUP00000012389	ENSOCUP00000015384	Fork-head domain-containing protein.	Phosphoenolpyruvate carboxykinase 1.	0.800