STRINGSTRING
MPO MPO UBTF UBTF CD44 CD44 DLK1 DLK1 FAM186A FAM186A ALK ALK NUP98 NUP98 SRC SRC KDM5A KDM5A NUP214 NUP214 PFN1 PFN1 TP53 TP53 PLOD2 PLOD2 PDGFRB PDGFRB PHF8 PHF8 SETD2 SETD2 SH2B3 SH2B3 MYH4 MYH4 CSF2 CSF2 BRCA1 BRCA1 CREBBP CREBBP DDX25 DDX25 PTPN11 PTPN11 FLT3 FLT3 WT1 WT1 KMT2D KMT2D ZEB1 ZEB1 KDM4C KDM4C TET2 TET2 NF1 NF1 PTPN1 PTPN1 FREM1 FREM1 STAT3 STAT3 HOXB6 HOXB6 MYB MYB RUNX2 RUNX2 PAX5 PAX5 PRKAR2B PRKAR2B RUNX1 RUNX1 IKZF1 IKZF1 IL27RA IL27RA ATM ATM EPOR EPOR JAK2 JAK2 LTF LTF HOXB5 HOXB5 HOXB8 HOXB8 IL6 IL6 MYH1 MYH1 DEK DEK NRAS NRAS ASXL1 ASXL1 ASNS ASNS DNMT3A DNMT3A HOXB9 HOXB9 PPM1D PPM1D MLF1 MLF1 KMT2C KMT2C APLP2 APLP2 EWSR1 EWSR1 MECOM MECOM MAD1L1 MAD1L1 SMARCA4 SMARCA4 ZMYND8 ZMYND8 CD34 CD34 DDX41 DDX41 CD19 CD19 KLF1 KLF1 IL7 IL7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MPOMyeloperoxidase. (725 aa)
UBTFUpstream binding transcription factor. (777 aa)
CD44CD44 molecule (Indian blood group). (761 aa)
DLK1Delta like non-canonical Notch ligand 1. (497 aa)
FAM186AUncharacterized protein. (636 aa)
ALKTyrosine-protein kinase receptor. (1448 aa)
NUP98Nucleoporin 98. (1825 aa)
SRCTyrosine-protein kinase. (589 aa)
KDM5ATransporter. (2271 aa)
NUP214Nucleoporin 214. (2126 aa)
PFN1Profilin; Belongs to the profilin family. (104 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (762 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
PHF8PHD finger protein 8. (1024 aa)
SETD2Uncharacterized protein. (625 aa)
SH2B3SH2B adaptor protein 3. (354 aa)
MYH4Myosin-4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
CSF2Uncharacterized protein. (144 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1852 aa)
CREBBPCREB binding protein. (2403 aa)
DDX25DEAD-box helicase 25. (482 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
WT1WT1 transcription factor. (302 aa)
KMT2DLysine methyltransferase 2D. (5446 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1080 aa)
KDM4CLysine demethylase 4C. (1050 aa)
TET2Tet methylcytosine dioxygenase 2. (2011 aa)
NF1Neurofibromin 1. (2841 aa)
PTPN1Protein tyrosine phosphatase non-receptor type 1. (495 aa)
FREM1FRAS1 related extracellular matrix 1. (2182 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
HOXB6Homeobox B6. (224 aa)
MYBMYB proto-oncogene, transcription factor. (758 aa)
RUNX2RUNX family transcription factor 2. (343 aa)
PAX5Paired box 5. (371 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (421 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (466 aa)
IKZF1IKAROS family zinc finger 1. (515 aa)
IL27RAInterleukin 27 receptor subunit alpha. (634 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
EPORErythropoietin receptor. (554 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
LTFLactotransferrin; Belongs to the transferrin family. (708 aa)
HOXB5Homeobox B5. (269 aa)
HOXB8Homeobox B8. (151 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
MYH1Myosin-4; Muscle contraction. (1938 aa)
DEKDEK proto-oncogene. (380 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ASXL1ASXL transcriptional regulator 1. (1512 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (532 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (843 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
PPM1DUncharacterized protein. (244 aa)
MLF1Myeloid leukemia factor 1. (286 aa)
KMT2CLysine methyltransferase 2C. (4911 aa)
APLP2Amyloid beta precursor like protein 2. (742 aa)
EWSR1Uncharacterized protein. (660 aa)
MECOMMDS1 and EVI1 complex locus. (1226 aa)
MAD1L1Uncharacterized protein. (434 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1653 aa)
ZMYND8Zinc finger MYND-type containing 8. (1184 aa)
CD34CD34 molecule. (415 aa)
DDX41DEAD-box helicase 41. (673 aa)
CD19CD19 molecule. (573 aa)
KLF1C2H2-type domain-containing protein. (553 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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