STRINGSTRING
KIT KIT CSF1R CSF1R CD40 CD40 CD79B CD79B COL5A1 COL5A1 CRHBP CRHBP ITGB4 ITGB4 CD4 CD4 BCR BCR G1TJR7_RABIT G1TJR7_RABIT IL4 IL4 ASPRV1 ASPRV1 G1TX56_RABIT G1TX56_RABIT CHD4 CHD4 PTGIR PTGIR CD3E CD3E LOC100344410 LOC100344410 CD63 CD63 H3-3A H3-3A CHD3 CHD3 HPRT1 HPRT1 LOC100345683 LOC100345683 MX1 MX1 CEBPB CEBPB H3C13 H3C13 ACVRL1 ACVRL1 IGLL1 IGLL1 SYK SYK PLCD3 PLCD3 PLXNC1 PLXNC1 CCND2 CCND2 H3F3B H3F3B HDAC9 HDAC9 LOC100357927 LOC100357927 RUNX1 RUNX1 TRIM63 TRIM63 PLXND1 PLXND1 PAX5 PAX5 CHIT1 CHIT1 BTK BTK EBF1 EBF1 HDAC5 HDAC5 THY1 THY1 IKZF2 IKZF2 ZAP70 ZAP70 LCK LCK CCR1 CCR1 SOCS2 SOCS2 BCL11A BCL11A CKAP4 CKAP4 CXCR2 CXCR2 GPRASP2 GPRASP2 GPR4 GPR4 TJP1 TJP1 PADI3 PADI3 GAPDH GAPDH CD6 CD6 ENSOCUP00000042583 ENSOCUP00000042583 INPP4A INPP4A ATP11A ATP11A CD38 CD38 PBX1 PBX1 HDAC2 HDAC2 CDK6 CDK6 HDAC1 HDAC1 CD19 CD19 BCL2 BCL2 CD86 CD86
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
CD40Uncharacterized protein. (494 aa)
CD79BCD79b molecule. (282 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (383 aa)
CRHBPCorticotropin releasing hormone binding protein. (382 aa)
ITGB4Integrin beta. (1708 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
BCRBCR activator of RhoGEF and GTPase. (1192 aa)
G1TJR7_RABITHistone H3; Belongs to the histone H3 family. (136 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
ASPRV1Aspartic peptidase retroviral like 1. (409 aa)
G1TX56_RABITHistone H3; Belongs to the histone H3 family. (136 aa)
CHD4Uncharacterized protein. (1940 aa)
PTGIRProstaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (201 aa)
LOC100344410Histone domain-containing protein. (136 aa)
CD63CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] (411 aa)
H3-3AHistone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
CHD3Chromodomain helicase DNA binding protein 3. (1901 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
LOC100345683Histone H3; Belongs to the histone H3 family. (136 aa)
MX1Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (697 aa)
CEBPBCCAAT enhancer binding protein beta. (353 aa)
H3C13Histone H3; Belongs to the histone H3 family. (136 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (327 aa)
IGLL1Lambda5. (208 aa)
SYKTyrosine-protein kinase. (630 aa)
PLCD3Phosphoinositide phospholipase C. (783 aa)
PLXNC1Plexin_cytopl domain-containing protein. (428 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (431 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1068 aa)
LOC100357927Histone domain-containing protein. (136 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (466 aa)
TRIM63Tripartite motif containing 63. (400 aa)
PLXND1Plexin D1. (1886 aa)
PAX5Paired box 5. (371 aa)
CHIT1Chitinase 1; Belongs to the glycosyl hydrolase 18 family. (464 aa)
BTKTyrosine-protein kinase. (659 aa)
EBF1EBF transcription factor 1. (591 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1115 aa)
THY1Thy-1 cell surface antigen. (161 aa)
IKZF2IKAROS family zinc finger 2. (540 aa)
ZAP70Tyrosine-protein kinase. (623 aa)
LCKTyrosine-protein kinase. (637 aa)
CCR1Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (351 aa)
SOCS2Suppressor of cytokine signaling 2. (307 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (975 aa)
CKAP4Cytoskeleton associated protein 4. (566 aa)
CXCR2C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). (357 aa)
GPRASP2G protein-coupled receptor associated sorting protein 2. (866 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (361 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1815 aa)
PADI3Peptidyl arginine deiminase 3. (665 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
CD6CD6 molecule. (683 aa)
ENSOCUP00000042583Histone H3; Belongs to the histone H3 family. (115 aa)
INPP4AInositol polyphosphate-4-phosphatase type I A. (1189 aa)
ATP11APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1065 aa)
CD38ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. (299 aa)
PBX1PBX homeobox 1. (430 aa)
HDAC2Histone deacetylase 2. (581 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (349 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (550 aa)
CD19CD19 molecule. (573 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
CD86T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. (336 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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