16 items (Oryctolagus cuniculus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
	IRF8	Interferon regulatory factor 8. (455 aa)
	BLNK	B cell linker. (274 aa)
	IRF4	Interferon regulatory factor 4. (451 aa)
	PAX5	Paired box 5. (371 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	BCLAF1	BCL2 associated transcription factor 1. (921 aa)
	SYK	Tyrosine-protein kinase. (630 aa)
	IGLL1	Lambda5. (208 aa)
	SPIB	ETS domain-containing protein. (158 aa)
	IGHM-2	Ig-like domain-containing protein. (167 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
	RAG2	V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (527 aa)
	IGHM-3	Ig-like domain-containing protein. (167 aa)
	BCL2	BH4_2 domain-containing protein. (389 aa)
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BCL2	ENSOCUP00000012638	ENSOCUP00000036189	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BH4_2 domain-containing protein.	0.700
ATM	GAPDH	ENSOCUP00000012638	ENSOCUP00000044112	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.732
BCL2	ATM	ENSOCUP00000036189	ENSOCUP00000012638	BH4_2 domain-containing protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.700
BCL2	BCLAF1	ENSOCUP00000036189	ENSOCUP00000014070	BH4_2 domain-containing protein.	BCL2 associated transcription factor 1.	0.748
BCL2	GAPDH	ENSOCUP00000036189	ENSOCUP00000044112	BH4_2 domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.916
BCL2	IGHM-2	ENSOCUP00000036189	ENSOCUP00000018495	BH4_2 domain-containing protein.	Ig-like domain-containing protein.	0.650
BCL2	IGHM-3	ENSOCUP00000036189	ENSOCUP00000025645	BH4_2 domain-containing protein.	Ig-like domain-containing protein.	0.650
BCL2	IL7	ENSOCUP00000036189	ENSOCUP00000038193	BH4_2 domain-containing protein.	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	0.653
BCL2	IRF4	ENSOCUP00000036189	ENSOCUP00000008085	BH4_2 domain-containing protein.	Interferon regulatory factor 4.	0.523
BCL2	PAX5	ENSOCUP00000036189	ENSOCUP00000010574	BH4_2 domain-containing protein.	Paired box 5.	0.541
BCL2	SYK	ENSOCUP00000036189	ENSOCUP00000015068	BH4_2 domain-containing protein.	Tyrosine-protein kinase.	0.459
BCLAF1	BCL2	ENSOCUP00000014070	ENSOCUP00000036189	BCL2 associated transcription factor 1.	BH4_2 domain-containing protein.	0.748
BLNK	IGHM-2	ENSOCUP00000002488	ENSOCUP00000018495	B cell linker.	Ig-like domain-containing protein.	0.494
BLNK	IGHM-3	ENSOCUP00000002488	ENSOCUP00000025645	B cell linker.	Ig-like domain-containing protein.	0.495
BLNK	IGLL1	ENSOCUP00000002488	ENSOCUP00000015640	B cell linker.	Lambda5.	0.684
BLNK	IRF4	ENSOCUP00000002488	ENSOCUP00000008085	B cell linker.	Interferon regulatory factor 4.	0.520
BLNK	IRF8	ENSOCUP00000002488	ENSOCUP00000000464	B cell linker.	Interferon regulatory factor 8.	0.417
BLNK	PAX5	ENSOCUP00000002488	ENSOCUP00000010574	B cell linker.	Paired box 5.	0.581
BLNK	SPIB	ENSOCUP00000002488	ENSOCUP00000017492	B cell linker.	ETS domain-containing protein.	0.567
BLNK	SYK	ENSOCUP00000002488	ENSOCUP00000015068	B cell linker.	Tyrosine-protein kinase.	0.963