(16 nodes) (2020) Poison-Exon Inclusion in DHX9 Reduces Its Expression and Sensitizes Ewing Sarcoma Cells to Chemotherapeutic Treatment. network (Oryctolagus cuniculus)

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Your Input:
	SRSF5	Serine and arginine rich splicing factor 5. (276 aa)
	SRSF3	Serine and arginine rich splicing factor 3. (164 aa)
	PXDNL	Peroxidasin like. (1467 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (471 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (769 aa)
	DHX9	DExH-box helicase 9. (1298 aa)
	SRSF10	Serine and arginine rich splicing factor 10. (262 aa)
	HNRNPL	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
	PXDN	Peroxidasin. (1411 aa)
	FUS	FUS RNA binding protein. (517 aa)
	SRSF1	Uncharacterized protein. (440 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (431 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
	HNRNPK	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (463 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCND2	EZH2	ENSOCUP00000013388	ENSOCUP00000041806	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.559
CCND2	GAPDH	ENSOCUP00000013388	ENSOCUP00000044112	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.771
CCND2	MYC	ENSOCUP00000013388	ENSOCUP00000012281	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.829
CCND2	PXDN	ENSOCUP00000013388	ENSOCUP00000022906	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Peroxidasin.	0.659
CCND2	PXDNL	ENSOCUP00000013388	ENSOCUP00000004823	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Peroxidasin like.	0.659
DHX9	FUS	ENSOCUP00000029909	ENSOCUP00000020899	DExH-box helicase 9.	FUS RNA binding protein.	0.710
DHX9	HNRNPK	ENSOCUP00000029909	ENSOCUP00000008932	DExH-box helicase 9.	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	0.771
DHX9	HNRNPL	ENSOCUP00000029909	ENSOCUP00000023948	DExH-box helicase 9.	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	0.829
DHX9	SRSF1	ENSOCUP00000029909	ENSOCUP00000015181	DExH-box helicase 9.	Uncharacterized protein.	0.752
DHX9	SRSF3	ENSOCUP00000029909	ENSOCUP00000005776	DExH-box helicase 9.	Serine and arginine rich splicing factor 3.	0.774
EZH2	CCND2	ENSOCUP00000041806	ENSOCUP00000013388	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.559
EZH2	GAPDH	ENSOCUP00000041806	ENSOCUP00000044112	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.752
EZH2	HNRNPK	ENSOCUP00000041806	ENSOCUP00000008932	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	0.444
EZH2	MYC	ENSOCUP00000041806	ENSOCUP00000012281	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.908
EZH2	NR0B1	ENSOCUP00000041806	ENSOCUP00000000025	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Nuclear receptor subfamily 0 group B member 1.	0.497
EZH2	PXDN	ENSOCUP00000041806	ENSOCUP00000022906	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Peroxidasin.	0.615
EZH2	PXDNL	ENSOCUP00000041806	ENSOCUP00000004823	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Peroxidasin like.	0.615
FUS	DHX9	ENSOCUP00000020899	ENSOCUP00000029909	FUS RNA binding protein.	DExH-box helicase 9.	0.710
FUS	GAPDH	ENSOCUP00000020899	ENSOCUP00000044112	FUS RNA binding protein.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.609
FUS	HNRNPK	ENSOCUP00000020899	ENSOCUP00000008932	FUS RNA binding protein.	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	0.781