STRINGSTRING
ECT2 ECT2 BCL6 BCL6 CTRL CTRL IL7 IL7 CNOT3 CNOT3 CD19 CD19 BCL2 BCL2 KIT KIT DYRK1A DYRK1A ZFP36L2 ZFP36L2 IGHM-3 IGHM-3 PRMT1 PRMT1 RAG2 RAG2 RAG1 RAG1 CD3E CD3E CDKN2D CDKN2D IGHM-2 IGHM-2 ZFP36L1 ZFP36L1 PTBP3 PTBP3 PTBP2 PTBP2 ELAVL1 ELAVL1 CCND2 CCND2 CD93 CD93 FOXO1 FOXO1 MYC MYC CDKN1B CDKN1B CDC25B CDC25B RHOA RHOA KIF2C KIF2C PAX5 PAX5 IRF4 IRF4 EBF1 EBF1 CDKN2C CDKN2C SAMHD1 SAMHD1 BCL2L11 BCL2L11 IRF8 IRF8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ECT2Epithelial cell transforming 2. (952 aa)
BCL6BCL6 transcription repressor. (723 aa)
CTRLChymotrypsin like; Belongs to the peptidase S1 family. (249 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
CNOT3Uncharacterized protein. (904 aa)
CD19CD19 molecule. (573 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
DYRK1ADual-specificity tyrosine-phosphorylation-regulated kinase 1A. (829 aa)
ZFP36L2ZFP36 ring finger protein like 2. (467 aa)
IGHM-3Ig-like domain-containing protein. (167 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
RAG2V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (527 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (201 aa)
CDKN2DANK_REP_REGION domain-containing protein. (310 aa)
IGHM-2Ig-like domain-containing protein. (167 aa)
ZFP36L1Uncharacterized protein. (338 aa)
PTBP3Polypyrimidine tract binding protein 3. (585 aa)
PTBP2Polypyrimidine tract binding protein 2. (536 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (382 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (431 aa)
CD93CD93 molecule. (653 aa)
FOXO1Fork-head domain-containing protein. (613 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CDC25BCell division cycle 25B. (413 aa)
RHOARas homolog family member A. (193 aa)
KIF2CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (725 aa)
PAX5Paired box 5. (371 aa)
IRF4Interferon regulatory factor 4. (451 aa)
EBF1EBF transcription factor 1. (591 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (616 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (194 aa)
IRF8Interferon regulatory factor 8. (455 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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