40 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (769 aa)
	LOC100348776	C-C motif chemokine. (93 aa)
	BCL11A	BAF chromatin remodeling complex subunit BCL11A. (975 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
	RAD21	RAD21 cohesin complex component. (630 aa)
	TLR2	TIR domain-containing protein; Belongs to the Toll-like receptor family. (784 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (830 aa)
	KLF3	Kruppel like factor 3. (436 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	APH1B	Aph-1 homolog B, gamma-secretase subunit. (240 aa)
	EBF1	EBF transcription factor 1. (591 aa)
	CD69	CD69 molecule. (201 aa)
	FOXP3	Forkhead box P3. (455 aa)
	PAX5	Paired box 5. (371 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
	FOXO1	Fork-head domain-containing protein. (613 aa)
	TCF7	Transcription factor 7. (319 aa)
	LIN28B	Lin-28 homolog B. (258 aa)
	IGLL1	Lambda5. (208 aa)
	TLR1	TIR domain-containing protein; Belongs to the Toll-like receptor family. (796 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	CXCR5	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	DDX58	DExD/H-box helicase 58. (954 aa)
	CXCL13	C-X-C motif chemokine ligand 13. (105 aa)
	YY1	Uncharacterized protein. (190 aa)
	NLRC3	NLR family CARD domain containing 3. (992 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
	RAG2	V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (527 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1031 aa)
	TSLP	Uncharacterized protein. (149 aa)
	CD5	Uncharacterized protein. (488 aa)
	SLAMF1	Signaling lymphocytic activation molecule family member 1. (340 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1192 aa)
	CTCF	CCCTC-binding factor. (738 aa)
	CCL4	C-C motif chemokine 4. (96 aa)
	CD19	CD19 molecule. (573 aa)
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
	LEF1	Lymphoid enhancer binding factor 1. (414 aa)
	BHLHE41	BHLH domain-containing protein. (122 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL11A	EBF1	ENSOCUP00000001042	ENSOCUP00000007763	BAF chromatin remodeling complex subunit BCL11A.	EBF transcription factor 1.	0.523
BCL11A	EZH2	ENSOCUP00000001042	ENSOCUP00000041806	BAF chromatin remodeling complex subunit BCL11A.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.429
BCL11A	PAX5	ENSOCUP00000001042	ENSOCUP00000010574	BAF chromatin remodeling complex subunit BCL11A.	Paired box 5.	0.521
CCL4	CCR7	ENSOCUP00000036404	ENSOCUP00000017477	C-C motif chemokine 4.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.888
CCL4	CD19	ENSOCUP00000036404	ENSOCUP00000036537	C-C motif chemokine 4.	CD19 molecule.	0.488
CCL4	CD69	ENSOCUP00000036404	ENSOCUP00000007818	C-C motif chemokine 4.	CD69 molecule.	0.500
CCL4	CXCL13	ENSOCUP00000036404	ENSOCUP00000019487	C-C motif chemokine 4.	C-X-C motif chemokine ligand 13.	0.993
CCL4	CXCR5	ENSOCUP00000036404	ENSOCUP00000018534	C-C motif chemokine 4.	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.644
CCL4	FOXP3	ENSOCUP00000036404	ENSOCUP00000008733	C-C motif chemokine 4.	Forkhead box P3.	0.554
CCL4	IL6	ENSOCUP00000036404	ENSOCUP00000017266	C-C motif chemokine 4.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.906
CCL4	IL7	ENSOCUP00000036404	ENSOCUP00000038193	C-C motif chemokine 4.	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	0.736
CCL4	LOC100348776	ENSOCUP00000036404	ENSOCUP00000000669	C-C motif chemokine 4.	C-C motif chemokine.	0.957
CCL4	TLR2	ENSOCUP00000036404	ENSOCUP00000002918	C-C motif chemokine 4.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.596
CCL4	TLR4	ENSOCUP00000036404	ENSOCUP00000001909	C-C motif chemokine 4.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.647
CCR7	CCL4	ENSOCUP00000017477	ENSOCUP00000036404	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 4.	0.888
CCR7	CD19	ENSOCUP00000017477	ENSOCUP00000036537	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD19 molecule.	0.853
CCR7	CD5	ENSOCUP00000017477	ENSOCUP00000023266	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.891
CCR7	CD69	ENSOCUP00000017477	ENSOCUP00000007818	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD69 molecule.	0.863
CCR7	CXCL13	ENSOCUP00000017477	ENSOCUP00000019487	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine ligand 13.	0.994
CCR7	CXCR5	ENSOCUP00000017477	ENSOCUP00000018534	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.816