node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL2 | CASP3 | ENSOCUP00000036189 | ENSOCUP00000036614 | BH4_2 domain-containing protein. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | 0.986 |
BCL2 | CDK2 | ENSOCUP00000036189 | ENSOCUP00000034758 | BH4_2 domain-containing protein. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.832 |
CASP3 | BCL2 | ENSOCUP00000036614 | ENSOCUP00000036189 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | BH4_2 domain-containing protein. | 0.986 |
CASP3 | CDK2 | ENSOCUP00000036614 | ENSOCUP00000034758 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.861 |
CASP3 | NEDD8 | ENSOCUP00000036614 | ENSOCUP00000002526 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.408 |
CDK2 | BCL2 | ENSOCUP00000034758 | ENSOCUP00000036189 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | BH4_2 domain-containing protein. | 0.832 |
CDK2 | CASP3 | ENSOCUP00000034758 | ENSOCUP00000036614 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | 0.861 |
CDK2 | CUL1 | ENSOCUP00000034758 | ENSOCUP00000002198 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | Cullin 1; Belongs to the cullin family. | 0.967 |
CDK2 | CUL3 | ENSOCUP00000034758 | ENSOCUP00000031324 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | Cullin 3; Belongs to the cullin family. | 0.580 |
CDK2 | NEDD8 | ENSOCUP00000034758 | ENSOCUP00000002526 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.726 |
CUL1 | CDK2 | ENSOCUP00000002198 | ENSOCUP00000034758 | Cullin 1; Belongs to the cullin family. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.967 |
CUL1 | CUL2 | ENSOCUP00000002198 | ENSOCUP00000012675 | Cullin 1; Belongs to the cullin family. | Cullin 2; Belongs to the cullin family. | 0.742 |
CUL1 | CUL3 | ENSOCUP00000002198 | ENSOCUP00000031324 | Cullin 1; Belongs to the cullin family. | Cullin 3; Belongs to the cullin family. | 0.887 |
CUL1 | CUL4A | ENSOCUP00000002198 | ENSOCUP00000008283 | Cullin 1; Belongs to the cullin family. | Cullin 4A; Belongs to the cullin family. | 0.903 |
CUL1 | CUL4B | ENSOCUP00000002198 | ENSOCUP00000040452 | Cullin 1; Belongs to the cullin family. | Cullin 4B; Belongs to the cullin family. | 0.845 |
CUL1 | CUL5 | ENSOCUP00000002198 | ENSOCUP00000009389 | Cullin 1; Belongs to the cullin family. | Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] | 0.865 |
CUL1 | CUL7 | ENSOCUP00000002198 | ENSOCUP00000001360 | Cullin 1; Belongs to the cullin family. | Cullin 7; Belongs to the cullin family. | 0.617 |
CUL1 | CUL9 | ENSOCUP00000002198 | ENSOCUP00000002529 | Cullin 1; Belongs to the cullin family. | Cullin 9; Belongs to the cullin family. | 0.491 |
CUL1 | DDB1 | ENSOCUP00000002198 | ENSOCUP00000001429 | Cullin 1; Belongs to the cullin family. | Damage specific DNA binding protein 1. | 0.960 |
CUL1 | DDB2 | ENSOCUP00000002198 | ENSOCUP00000001792 | Cullin 1; Belongs to the cullin family. | Damage specific DNA binding protein 2. | 0.593 |