(15 nodes) (2020) Aging affects sex- and organ-specific trace element profiles in mice. network (Oryctolagus cuniculus)

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Your Input:
	PXDNL	Peroxidasin like. (1467 aa)
	LOC103350073	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
	ATP7A	ATPase copper transporting alpha. (1499 aa)
	TFRC	Transferrin receptor. (763 aa)
	MT4	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	HPRT1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
	RPL13A	Uncharacterized protein. (135 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
	PXDN	Peroxidasin. (1411 aa)
	HAMP	Hepcidin antimicrobial peptide. (83 aa)
	SLC48A1	Solute carrier family 48 member 1. (156 aa)
	ATP7B	ATPase copper transporting beta. (1465 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
	MT1B	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (56 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP7A	ATP7B	ENSOCUP00000012171	ENSOCUP00000043559	ATPase copper transporting alpha.	ATPase copper transporting beta.	0.905
ATP7A	LOC103350073	ENSOCUP00000012171	ENSOCUP00000006271	ATPase copper transporting alpha.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.728
ATP7A	MT1B	ENSOCUP00000012171	ENSOCUP00000047546	ATPase copper transporting alpha.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.727
ATP7A	MT4	ENSOCUP00000012171	ENSOCUP00000014837	ATPase copper transporting alpha.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.728
ATP7A	TFRC	ENSOCUP00000012171	ENSOCUP00000014641	ATPase copper transporting alpha.	Transferrin receptor.	0.419
ATP7B	ATP7A	ENSOCUP00000043559	ENSOCUP00000012171	ATPase copper transporting beta.	ATPase copper transporting alpha.	0.905
ATP7B	LOC103350073	ENSOCUP00000043559	ENSOCUP00000006271	ATPase copper transporting beta.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.741
ATP7B	MT1B	ENSOCUP00000043559	ENSOCUP00000047546	ATPase copper transporting beta.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.741
ATP7B	MT4	ENSOCUP00000043559	ENSOCUP00000014837	ATPase copper transporting beta.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.741
GAPDH	HAMP	ENSOCUP00000044112	ENSOCUP00000024006	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Hepcidin antimicrobial peptide.	0.457
GAPDH	HPRT1	ENSOCUP00000044112	ENSOCUP00000017690	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.899
GAPDH	IL1B	ENSOCUP00000044112	ENSOCUP00000021869	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.914
GAPDH	IL6	ENSOCUP00000044112	ENSOCUP00000017266	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.914
GAPDH	LOC103350073	ENSOCUP00000044112	ENSOCUP00000006271	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.411
GAPDH	MT1B	ENSOCUP00000044112	ENSOCUP00000047546	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.426
GAPDH	MT4	ENSOCUP00000044112	ENSOCUP00000014837	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.408
GAPDH	PXDN	ENSOCUP00000044112	ENSOCUP00000022906	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Peroxidasin.	0.982
GAPDH	PXDNL	ENSOCUP00000044112	ENSOCUP00000004823	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Peroxidasin like.	0.982
GAPDH	RPL13A	ENSOCUP00000044112	ENSOCUP00000021167	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Uncharacterized protein.	0.996
GAPDH	TFRC	ENSOCUP00000044112	ENSOCUP00000014641	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Transferrin receptor.	0.711