STRINGSTRING
CUL4A CUL4A CDK12 CDK12 DDB1 DDB1 RBM23 RBM23 CUL1 CUL1 NEDD8 NEDD8 CCNH CCNH CDK7 CDK7 UBA1 UBA1 CUL5 CUL5 UBA6 UBA6 CUL2 CUL2 CDK13 CDK13 UBE2M UBE2M RBM39 RBM39 UBE2G1 UBE2G1 UBE2Z UBE2Z CUL3 CUL3 CRBN CRBN UBE2F UBE2F MLH1 MLH1 VCL VCL CUL4B CUL4B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
CDK12Cyclin dependent kinase 12. (1492 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
RBM23RNA binding motif protein 23. (444 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
NEDD8NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
CCNHCyclin H; Belongs to the cyclin family. (323 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
UBA1Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity). (1058 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
UBA6Ubiquitin like modifier activating enzyme 6. (1052 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
CDK13Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (418 aa)
UBE2MUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa)
RBM39RNA binding motif protein 39 isoform a (Predicted). (530 aa)
UBE2G1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
UBE2ZUbiquitin conjugating enzyme E2 Z. (291 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
CRBNCereblon. (491 aa)
UBE2FUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (220 aa)
MLH1MutL homolog 1. (800 aa)
VCLVinculin. (1241 aa)
CUL4BCullin 4B; Belongs to the cullin family. (901 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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