Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCA1 | ICAM1 | ENSOCUP00000046484 | ENSOCUP00000027126 | ATP binding cassette subfamily A member 1. | Intercellular adhesion molecule 1. | 0.610 |
| ABCA1 | IFNG | ENSOCUP00000046484 | ENSOCUP00000039594 | ATP binding cassette subfamily A member 1. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.491 |
| ABCA1 | IL10 | ENSOCUP00000046484 | ENSOCUP00000019534 | ATP binding cassette subfamily A member 1. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.543 |
| ABCA1 | IL6 | ENSOCUP00000046484 | ENSOCUP00000017266 | ATP binding cassette subfamily A member 1. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.677 |
| ABCA1 | JAK2 | ENSOCUP00000046484 | ENSOCUP00000014491 | ATP binding cassette subfamily A member 1. | Tyrosine-protein kinase. | 0.641 |
| ABCA1 | LEP | ENSOCUP00000046484 | ENSOCUP00000008782 | ATP binding cassette subfamily A member 1. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.445 |
| ABCA1 | NR1H3 | ENSOCUP00000046484 | ENSOCUP00000001808 | ATP binding cassette subfamily A member 1. | Liver X receptor alpha. | 0.963 |
| ABCA1 | PCSK9 | ENSOCUP00000046484 | ENSOCUP00000046637 | ATP binding cassette subfamily A member 1. | Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. | 0.763 |
| ABCA1 | SCARB1 | ENSOCUP00000046484 | ENSOCUP00000037035 | ATP binding cassette subfamily A member 1. | Scavenger receptor class B member 1; Belongs to the CD36 family. | 0.803 |
| ABCA1 | STAT3 | ENSOCUP00000046484 | ENSOCUP00000009494 | ATP binding cassette subfamily A member 1. | Signal transducer and activator of transcription. | 0.818 |
| CLCF1 | CTF1 | ENSOCUP00000035345 | ENSOCUP00000004929 | Cardiotrophin like cytokine factor 1. | Cardiotrophin 1. | 0.681 |
| CLCF1 | JAK1 | ENSOCUP00000035345 | ENSOCUP00000005398 | Cardiotrophin like cytokine factor 1. | Tyrosine-protein kinase. | 0.429 |
| CLCF1 | JAK2 | ENSOCUP00000035345 | ENSOCUP00000014491 | Cardiotrophin like cytokine factor 1. | Tyrosine-protein kinase. | 0.525 |
| CLCF1 | OSM | ENSOCUP00000035345 | ENSOCUP00000008790 | Cardiotrophin like cytokine factor 1. | Uncharacterized protein. | 0.547 |
| CLCF1 | TYK2 | ENSOCUP00000035345 | ENSOCUP00000036146 | Cardiotrophin like cytokine factor 1. | Non-specific protein-tyrosine kinase. | 0.424 |
| CSF2 | EPO | ENSOCUP00000002976 | ENSOCUP00000004681 | Uncharacterized protein. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.835 |
| CSF2 | F3 | ENSOCUP00000002976 | ENSOCUP00000029185 | Uncharacterized protein. | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.446 |
| CSF2 | ICAM1 | ENSOCUP00000002976 | ENSOCUP00000027126 | Uncharacterized protein. | Intercellular adhesion molecule 1. | 0.742 |
| CSF2 | IFNG | ENSOCUP00000002976 | ENSOCUP00000039594 | Uncharacterized protein. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.984 |
| CSF2 | IL10 | ENSOCUP00000002976 | ENSOCUP00000019534 | Uncharacterized protein. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.928 |
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