(21 nodes) (2020) An Efficient Screen for Cell-Intrinsic Factors Identifies the Chaperonin CCT and Multiple Conserved Mechanisms as Mediating Dendrite Morphogenesis. network (Oryctolagus cuniculus)

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Your Input:
	CD4	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
	PPP2R2B	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (509 aa)
	CCT4	T-complex protein 1 subunit delta. (551 aa)
	HTT	Huntingtin. (3044 aa)
	EIF5B	Eukaryotic translation initiation factor 5B. (1264 aa)
	SYT1	Synaptotagmin 1. (447 aa)
	CCT7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa)
	CCT5	Chaperonin containing TCP1 subunit 5. (541 aa)
	PITPNA	Phosphatidylinositol transfer protein alpha isoform; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes; Belongs to the PtdIns transfer protein family. PI transfer class I subfamily. (270 aa)
	WARS2	Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (393 aa)
	EIF3B	Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form [...] (679 aa)
	EIF3I	Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (325 aa)
	QARS1	Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (775 aa)
	CCT8	Chaperonin containing TCP1 subunit 8. (556 aa)
	CCT3	T-complex protein 1 subunit gamma. (545 aa)
	DCTN2	Dynactin subunit 2. (407 aa)
	PCF11	PCF11 cleavage and polyadenylation factor subunit. (1684 aa)
	EIF3H	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (366 aa)
	MAN2A1	Alpha-mannosidase. (1172 aa)
	MAN2A2	Alpha-mannosidase. (1124 aa)
	WARS1	Tryptophan--tRNA ligase, cytoplasmic; T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). (506 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCT3	CCT4	ENSOCUP00000000120	ENSOCUP00000028222	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit delta.	0.999
CCT3	CCT5	ENSOCUP00000000120	ENSOCUP00000018287	T-complex protein 1 subunit gamma.	Chaperonin containing TCP1 subunit 5.	0.999
CCT3	CCT7	ENSOCUP00000000120	ENSOCUP00000018309	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.999
CCT3	CCT8	ENSOCUP00000000120	ENSOCUP00000002283	T-complex protein 1 subunit gamma.	Chaperonin containing TCP1 subunit 8.	0.993
CCT3	EIF3B	ENSOCUP00000000120	ENSOCUP00000008873	T-complex protein 1 subunit gamma.	Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form [...]	0.453
CCT3	EIF3I	ENSOCUP00000000120	ENSOCUP00000006589	T-complex protein 1 subunit gamma.	Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]	0.552
CCT4	CCT3	ENSOCUP00000028222	ENSOCUP00000000120	T-complex protein 1 subunit delta.	T-complex protein 1 subunit gamma.	0.999
CCT4	CCT5	ENSOCUP00000028222	ENSOCUP00000018287	T-complex protein 1 subunit delta.	Chaperonin containing TCP1 subunit 5.	0.999
CCT4	CCT7	ENSOCUP00000028222	ENSOCUP00000018309	T-complex protein 1 subunit delta.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.999
CCT4	CCT8	ENSOCUP00000028222	ENSOCUP00000002283	T-complex protein 1 subunit delta.	Chaperonin containing TCP1 subunit 8.	0.998
CCT4	EIF3B	ENSOCUP00000028222	ENSOCUP00000008873	T-complex protein 1 subunit delta.	Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form [...]	0.848
CCT4	EIF3H	ENSOCUP00000028222	ENSOCUP00000039136	T-complex protein 1 subunit delta.	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]	0.406
CCT4	EIF3I	ENSOCUP00000028222	ENSOCUP00000006589	T-complex protein 1 subunit delta.	Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]	0.722
CCT4	EIF5B	ENSOCUP00000028222	ENSOCUP00000026193	T-complex protein 1 subunit delta.	Eukaryotic translation initiation factor 5B.	0.410
CCT5	CCT3	ENSOCUP00000018287	ENSOCUP00000000120	Chaperonin containing TCP1 subunit 5.	T-complex protein 1 subunit gamma.	0.999
CCT5	CCT4	ENSOCUP00000018287	ENSOCUP00000028222	Chaperonin containing TCP1 subunit 5.	T-complex protein 1 subunit delta.	0.999
CCT5	CCT7	ENSOCUP00000018287	ENSOCUP00000018309	Chaperonin containing TCP1 subunit 5.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.999
CCT5	CCT8	ENSOCUP00000018287	ENSOCUP00000002283	Chaperonin containing TCP1 subunit 5.	Chaperonin containing TCP1 subunit 8.	0.997
CCT5	EIF3B	ENSOCUP00000018287	ENSOCUP00000008873	Chaperonin containing TCP1 subunit 5.	Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form [...]	0.528
CCT5	EIF3I	ENSOCUP00000018287	ENSOCUP00000006589	Chaperonin containing TCP1 subunit 5.	Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]	0.674