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NEDD8 NEDD8 NAE1 NAE1 CUL7 CUL7 CUL1 CUL1 UBE2L3 UBE2L3 RNF4 RNF4 G1SQP5_RABIT G1SQP5_RABIT UBA3 UBA3 ASB9 ASB9 UBA1 UBA1 ELOB ELOB CUL5 CUL5 ARIH1 ARIH1 CUL2 CUL2 ARIH2 ARIH2 G1TG12_RABIT G1TG12_RABIT G1TM59_RABIT G1TM59_RABIT SKP1 SKP1 G1TU65_RABIT G1TU65_RABIT SUMO2 SUMO2 UBE2D2 UBE2D2 UBE2D1 UBE2D1 ELOC ELOC SUMO1 SUMO1 UBE2F UBE2F ENSOCUP00000041916 ENSOCUP00000041916
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
NEDD8NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (537 aa)
CUL7Cullin 7; Belongs to the cullin family. (1728 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
UBE2L3Ubiquitin conjugating enzyme E2 L3; Belongs to the ubiquitin-conjugating enzyme family. (211 aa)
RNF4RING-type domain-containing protein. (190 aa)
G1SQP5_RABITSmall ubiquitin-related modifier. (95 aa)
UBA3Ubiquitin like modifier activating enzyme 3. (463 aa)
ASB9Ankyrin repeat and SOCS box containing 9. (294 aa)
UBA1Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity). (1058 aa)
ELOBElongin B. (118 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
ARIH1RBR-type E3 ubiquitin transferase. (500 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
ARIH2RBR-type E3 ubiquitin transferase. (493 aa)
G1TG12_RABITSmall ubiquitin-related modifier. (87 aa)
G1TM59_RABITSmall ubiquitin-related modifier. (94 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
G1TU65_RABITSmall ubiquitin-related modifier. (95 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
UBE2D2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (317 aa)
UBE2D1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
UBE2FUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (220 aa)
ENSOCUP00000041916Small ubiquitin-related modifier. (109 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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