STRINGSTRING
JAG1 JAG1 MDM4 MDM4 PRPF8 PRPF8 FGF2 FGF2 SF3B3 SF3B3 ZRSR2 ZRSR2 SF3B4 SF3B4 ATP5F1C ATP5F1C RBM4 RBM4 SF3A3 SF3A3 SRSF3 SRSF3 SRPK2 SRPK2 LMNB1 LMNB1 SF3B5 SF3B5 NUMBL NUMBL NUMB NUMB BMP4 BMP4 EGF EGF HEY1 HEY1 SRSF1 SRSF1 APLNR APLNR IGF1 IGF1 RBM10 RBM10 GFI1 GFI1 LAS1L LAS1L HEY2 HEY2 CD34 CD34 NFIB NFIB ENSOCUP00000037873 ENSOCUP00000037873 MEIS2 MEIS2 DLL1 DLL1 SNRPE SNRPE RBFOX2 RBFOX2 SRC SRC GAPDH GAPDH ACTB ACTB PCBP2 PCBP2 MEIS1 MEIS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
PRPF8Pre-mRNA processing factor 8. (2335 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
SF3B3Splicing factor 3b subunit 3. (1189 aa)
ZRSR2Zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2. (485 aa)
SF3B4Splicing factor 3b subunit 4. (424 aa)
ATP5F1CATP synthase subunit gamma. (298 aa)
RBM4RNA-binding protein 4; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation [...] (365 aa)
SF3A3Splicing factor 3a subunit 3. (501 aa)
SRSF3Serine and arginine rich splicing factor 3. (164 aa)
SRPK2SRSF protein kinase 2. (739 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (609 aa)
SF3B5Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
NUMBLNUMB like endocytic adaptor protein. (672 aa)
NUMBNUMB endocytic adaptor protein. (604 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (452 aa)
SRSF1Uncharacterized protein. (440 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
RBM10RNA binding motif protein 10. (996 aa)
GFI1Growth factor independent 1 transcriptional repressor. (423 aa)
LAS1LLAS1 like, ribosome biogenesis factor. (717 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (338 aa)
CD34CD34 molecule. (415 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (586 aa)
ENSOCUP00000037873Uncharacterized protein. (411 aa)
MEIS2Meis homeobox 2. (477 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (754 aa)
SNRPESmall nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (92 aa)
RBFOX2RNA binding fox-1 homolog 2. (592 aa)
SRCTyrosine-protein kinase. (589 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
ACTBUncharacterized protein. (357 aa)
PCBP2Poly(rC) binding protein 2. (366 aa)
MEIS1Meis homeobox 1. (465 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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