(25 nodes) (2020) Rocking the Boat: The Decisive Roles of Rho Kinases During Oocyte, Blastocyst, and Stem Cell Development. network (Oryctolagus cuniculus)

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Predicted Interactions

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Your Input:
	RHOB	Ras homolog family member B. (196 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (346 aa)
	ROCK1	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...] (1352 aa)
	SLC9A1	Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
	LOC100356070	Profilin; Belongs to the profilin family. (153 aa)
	FHOD1	Formin homology 2 domain containing 1. (1137 aa)
	MSN	FERM domain-containing protein. (577 aa)
	FLNA	Uncharacterized protein. (2617 aa)
	PFN1	Profilin; Belongs to the profilin family. (104 aa)
	RABIF	RAB interacting factor. (123 aa)
	CDX2	Caudal type homeobox 2. (314 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (521 aa)
	STC1	Stanniocalcin 1. (247 aa)
	PFN2	Profilin; Belongs to the profilin family. (91 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	VIM	Vimentin; Belongs to the intermediate filament family. (466 aa)
	CFL2	Cofilin 2; Belongs to the actin-binding proteins ADF family. (195 aa)
	LOC103351183	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (254 aa)
	RHOA	Ras homolog family member A. (193 aa)
	RHOC	Uncharacterized protein. (422 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1815 aa)
	CXADR	Uncharacterized protein. (362 aa)
	PFN4	Uncharacterized protein; Belongs to the profilin family. (201 aa)
	EZR	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). (653 aa)
	RDX	Radixin. (643 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	LOC103351183	ENSOCUP00000036614	ENSOCUP00000011323	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.968
CASP3	OCLN	ENSOCUP00000036614	ENSOCUP00000004293	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family.	0.671
CASP3	PTEN	ENSOCUP00000036614	ENSOCUP00000007574	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.828
CASP3	RHOA	ENSOCUP00000036614	ENSOCUP00000011466	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Ras homolog family member A.	0.682
CASP3	ROCK1	ENSOCUP00000036614	ENSOCUP00000034408	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...]	0.924
CASP3	TJP1	ENSOCUP00000036614	ENSOCUP00000046568	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Tight junction protein 1; Belongs to the MAGUK family.	0.750
CASP3	VIM	ENSOCUP00000036614	ENSOCUP00000007960	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Vimentin; Belongs to the intermediate filament family.	0.731
CFL2	EZR	ENSOCUP00000008091	ENSOCUP00000040029	Cofilin 2; Belongs to the actin-binding proteins ADF family.	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).	0.717
CFL2	FLNA	ENSOCUP00000008091	ENSOCUP00000000761	Cofilin 2; Belongs to the actin-binding proteins ADF family.	Uncharacterized protein.	0.811
CFL2	LOC100356070	ENSOCUP00000008091	ENSOCUP00000019216	Cofilin 2; Belongs to the actin-binding proteins ADF family.	Profilin; Belongs to the profilin family.	0.903
CFL2	MSN	ENSOCUP00000008091	ENSOCUP00000000131	Cofilin 2; Belongs to the actin-binding proteins ADF family.	FERM domain-containing protein.	0.791
CFL2	PFN1	ENSOCUP00000008091	ENSOCUP00000000960	Cofilin 2; Belongs to the actin-binding proteins ADF family.	Profilin; Belongs to the profilin family.	0.901
CFL2	PFN2	ENSOCUP00000008091	ENSOCUP00000005248	Cofilin 2; Belongs to the actin-binding proteins ADF family.	Profilin; Belongs to the profilin family.	0.901
CFL2	PFN4	ENSOCUP00000008091	ENSOCUP00000042619	Cofilin 2; Belongs to the actin-binding proteins ADF family.	Uncharacterized protein; Belongs to the profilin family.	0.929
CFL2	PTEN	ENSOCUP00000008091	ENSOCUP00000007574	Cofilin 2; Belongs to the actin-binding proteins ADF family.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.411
CFL2	RABIF	ENSOCUP00000008091	ENSOCUP00000001902	Cofilin 2; Belongs to the actin-binding proteins ADF family.	RAB interacting factor.	0.511
CFL2	RDX	ENSOCUP00000008091	ENSOCUP00000037499	Cofilin 2; Belongs to the actin-binding proteins ADF family.	Radixin.	0.699
CFL2	RHOA	ENSOCUP00000008091	ENSOCUP00000011466	Cofilin 2; Belongs to the actin-binding proteins ADF family.	Ras homolog family member A.	0.869
CFL2	RHOB	ENSOCUP00000008091	ENSOCUP00000037384	Cofilin 2; Belongs to the actin-binding proteins ADF family.	Ras homolog family member B.	0.534
CFL2	RHOC	ENSOCUP00000008091	ENSOCUP00000016582	Cofilin 2; Belongs to the actin-binding proteins ADF family.	Uncharacterized protein.	0.607