(13 nodes) (2021) The Long Linker Region of Telomere-Binding Protein TRF2 Is Responsible for Interactions with Lamins. network (Oryctolagus cuniculus)

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Your Input:
	TOP1	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)
	HNRNPK	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (463 aa)
	MYB	MYB proto-oncogene, transcription factor. (758 aa)
	TOP3B	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (863 aa)
	HNRNPA1	Uncharacterized protein. (371 aa)
	SRSF1	Uncharacterized protein. (440 aa)
	NONO	Uncharacterized protein. (382 aa)
	HNRNPL	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
	DHX9	DExH-box helicase 9. (1298 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
	SFPQ	Splicing factor proline and glutamine rich. (545 aa)
	HNRNPA3	Uncharacterized protein. (378 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (609 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX5	DHX9	ENSOCUP00000043262	ENSOCUP00000029909	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DExH-box helicase 9.	0.969
DDX5	HNRNPA1	ENSOCUP00000043262	ENSOCUP00000011492	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.788
DDX5	HNRNPA3	ENSOCUP00000043262	ENSOCUP00000002378	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.587
DDX5	HNRNPK	ENSOCUP00000043262	ENSOCUP00000008932	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	0.819
DDX5	HNRNPL	ENSOCUP00000043262	ENSOCUP00000023948	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	0.426
DDX5	NONO	ENSOCUP00000043262	ENSOCUP00000017243	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.681
DDX5	SFPQ	ENSOCUP00000043262	ENSOCUP00000001616	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Splicing factor proline and glutamine rich.	0.722
DDX5	SRSF1	ENSOCUP00000043262	ENSOCUP00000015181	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.527
DDX5	TOP1	ENSOCUP00000043262	ENSOCUP00000007107	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.424
DHX9	DDX5	ENSOCUP00000029909	ENSOCUP00000043262	DExH-box helicase 9.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.969
DHX9	HNRNPA1	ENSOCUP00000029909	ENSOCUP00000011492	DExH-box helicase 9.	Uncharacterized protein.	0.851
DHX9	HNRNPA3	ENSOCUP00000029909	ENSOCUP00000002378	DExH-box helicase 9.	Uncharacterized protein.	0.647
DHX9	HNRNPK	ENSOCUP00000029909	ENSOCUP00000008932	DExH-box helicase 9.	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	0.771
DHX9	HNRNPL	ENSOCUP00000029909	ENSOCUP00000023948	DExH-box helicase 9.	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	0.829
DHX9	NONO	ENSOCUP00000029909	ENSOCUP00000017243	DExH-box helicase 9.	Uncharacterized protein.	0.593
DHX9	SFPQ	ENSOCUP00000029909	ENSOCUP00000001616	DExH-box helicase 9.	Splicing factor proline and glutamine rich.	0.798
DHX9	SRSF1	ENSOCUP00000029909	ENSOCUP00000015181	DExH-box helicase 9.	Uncharacterized protein.	0.752
DHX9	TOP1	ENSOCUP00000029909	ENSOCUP00000007107	DExH-box helicase 9.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.495
DHX9	TOP3B	ENSOCUP00000029909	ENSOCUP00000010585	DExH-box helicase 9.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.458
HNRNPA1	DDX5	ENSOCUP00000011492	ENSOCUP00000043262	Uncharacterized protein.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.788