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CA9 CA9 CA6 CA6 IL10 IL10 CA3 CA3 CA12 CA12 CA7 CA7 GFAP GFAP CA13 CA13 CS-6 CS-6 PLAT PLAT CA4 CA4 CA14 CA14 CA5B CA5B CA1 CA1 ALB ALB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CA9Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (435 aa)
CA6Alpha-carbonic anhydrase domain-containing protein; Belongs to the alpha-carbonic anhydrase family. (474 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
CA3Carbonic anhydrase 3; Belongs to the alpha-carbonic anhydrase family. (325 aa)
CA12Carbonic anhydrase 12; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family. (372 aa)
CA7Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (324 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (515 aa)
CA13Carbonic anhydrase 13; Belongs to the alpha-carbonic anhydrase family. (263 aa)
CS-6Neutrophil antibiotic peptide NP-5; Microbicidal activity; Belongs to the alpha-defensin family. (95 aa)
PLATUncharacterized protein. (594 aa)
CA4Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity). (416 aa)
CA14Carbonic anhydrase 14; Belongs to the alpha-carbonic anhydrase family. (337 aa)
CA5BCarbonic anhydrase 5B; Belongs to the alpha-carbonic anhydrase family. (317 aa)
CA1Carbonic anhydrase 1; Reversible hydration of carbon dioxide. (157 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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