node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPT2 | INS | ENSOCUP00000014299 | ENSOCUP00000020463 | Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.424 |
CPT2 | SLC2A4 | ENSOCUP00000014299 | ENSOCUP00000034640 | Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. | MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.465 |
DLL1 | GAPDH | ENSOCUP00000041831 | ENSOCUP00000044112 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.561 |
DLL1 | INS | ENSOCUP00000041831 | ENSOCUP00000020463 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.422 |
FST | GAPDH | ENSOCUP00000004047 | ENSOCUP00000044112 | Follistatin. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.414 |
FST | INS | ENSOCUP00000004047 | ENSOCUP00000020463 | Follistatin. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.494 |
FST | MSTN | ENSOCUP00000004047 | ENSOCUP00000010893 | Follistatin. | Myostatin. | 0.990 |
FST | MYF5 | ENSOCUP00000004047 | ENSOCUP00000023250 | Follistatin. | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. | 0.533 |
FST | MYOG | ENSOCUP00000004047 | ENSOCUP00000009928 | Follistatin. | Myogenin. | 0.556 |
FST | PAX7 | ENSOCUP00000004047 | ENSOCUP00000005326 | Follistatin. | Paired box 7. | 0.469 |
G1TJG6_RABIT | IFNG | ENSOCUP00000017094 | ENSOCUP00000039594 | Glyceraldehyde-3-phosphate dehydrogenase. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.742 |
G1TJG6_RABIT | IL1B | ENSOCUP00000017094 | ENSOCUP00000021869 | Glyceraldehyde-3-phosphate dehydrogenase. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.827 |
G1TJG6_RABIT | IL6 | ENSOCUP00000017094 | ENSOCUP00000017266 | Glyceraldehyde-3-phosphate dehydrogenase. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.849 |
G1TJG6_RABIT | INS | ENSOCUP00000017094 | ENSOCUP00000020463 | Glyceraldehyde-3-phosphate dehydrogenase. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.786 |
G1TJG6_RABIT | IRS1 | ENSOCUP00000017094 | ENSOCUP00000006209 | Glyceraldehyde-3-phosphate dehydrogenase. | Insulin receptor substrate 1. | 0.476 |
G1TJG6_RABIT | MYOG | ENSOCUP00000017094 | ENSOCUP00000009928 | Glyceraldehyde-3-phosphate dehydrogenase. | Myogenin. | 0.499 |
G1TYG1_RABIT | IFNG | ENSOCUP00000022125 | ENSOCUP00000039594 | Glyceraldehyde-3-phosphate dehydrogenase. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.742 |
G1TYG1_RABIT | IL1B | ENSOCUP00000022125 | ENSOCUP00000021869 | Glyceraldehyde-3-phosphate dehydrogenase. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.827 |
G1TYG1_RABIT | IL6 | ENSOCUP00000022125 | ENSOCUP00000017266 | Glyceraldehyde-3-phosphate dehydrogenase. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.849 |
G1TYG1_RABIT | INS | ENSOCUP00000022125 | ENSOCUP00000020463 | Glyceraldehyde-3-phosphate dehydrogenase. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.786 |