(8 nodes) (2021) Untargeted Metabolomic Characteristics of Skeletal Muscle Dysfunction in Rabbits Induced by a High Fat Diet. network (Oryctolagus cuniculus)

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Your Input:
	G6PC	Glucose-6-phosphatase catalytic subunit. (359 aa)
	G6PC2	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	GCG	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity). (180 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
	G6PC3	Glucose-6-phosphatase catalytic subunit 3. (562 aa)
	INSR	Tyrosine-protein kinase receptor. (1377 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G6PC	G6PC2	ENSOCUP00000013761	ENSOCUP00000001179	Glucose-6-phosphatase catalytic subunit.	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.939
G6PC	G6PC3	ENSOCUP00000013761	ENSOCUP00000033043	Glucose-6-phosphatase catalytic subunit.	Glucose-6-phosphatase catalytic subunit 3.	0.910
G6PC	GCG	ENSOCUP00000013761	ENSOCUP00000019727	Glucose-6-phosphatase catalytic subunit.	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	0.761
G6PC	IL6	ENSOCUP00000013761	ENSOCUP00000017266	Glucose-6-phosphatase catalytic subunit.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.416
G6PC	INS	ENSOCUP00000013761	ENSOCUP00000020463	Glucose-6-phosphatase catalytic subunit.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.817
G6PC	INSR	ENSOCUP00000013761	ENSOCUP00000042281	Glucose-6-phosphatase catalytic subunit.	Tyrosine-protein kinase receptor.	0.533
G6PC2	G6PC	ENSOCUP00000001179	ENSOCUP00000013761	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Glucose-6-phosphatase catalytic subunit.	0.939
G6PC2	G6PC3	ENSOCUP00000001179	ENSOCUP00000033043	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Glucose-6-phosphatase catalytic subunit 3.	0.908
G6PC2	GCG	ENSOCUP00000001179	ENSOCUP00000019727	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	0.743
G6PC2	INS	ENSOCUP00000001179	ENSOCUP00000020463	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.782
G6PC2	INSR	ENSOCUP00000001179	ENSOCUP00000042281	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Tyrosine-protein kinase receptor.	0.449
G6PC3	G6PC	ENSOCUP00000033043	ENSOCUP00000013761	Glucose-6-phosphatase catalytic subunit 3.	Glucose-6-phosphatase catalytic subunit.	0.910
G6PC3	G6PC2	ENSOCUP00000033043	ENSOCUP00000001179	Glucose-6-phosphatase catalytic subunit 3.	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.908
G6PC3	GCG	ENSOCUP00000033043	ENSOCUP00000019727	Glucose-6-phosphatase catalytic subunit 3.	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	0.728
G6PC3	INS	ENSOCUP00000033043	ENSOCUP00000020463	Glucose-6-phosphatase catalytic subunit 3.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.774
G6PC3	INSR	ENSOCUP00000033043	ENSOCUP00000042281	Glucose-6-phosphatase catalytic subunit 3.	Tyrosine-protein kinase receptor.	0.446
GCG	G6PC	ENSOCUP00000019727	ENSOCUP00000013761	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Glucose-6-phosphatase catalytic subunit.	0.761
GCG	G6PC2	ENSOCUP00000019727	ENSOCUP00000001179	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.743
GCG	G6PC3	ENSOCUP00000019727	ENSOCUP00000033043	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Glucose-6-phosphatase catalytic subunit 3.	0.728
GCG	IL6	ENSOCUP00000019727	ENSOCUP00000017266	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.632