23 items (Oryctolagus cuniculus) - STRING interaction network

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	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	JUN	BZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (677 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
	IL37	Interleukin-1. (280 aa)
	SPP1	Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (311 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	PTGS2	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)
	G1TC56_RABIT	TGFb_propeptide domain-containing protein. (168 aa)
	IL36A	Interleukin-1. (156 aa)
	SPARC	SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. (315 aa)
	RUNX2	RUNX family transcription factor 2. (343 aa)
	TGFB3	Transforming growth factor beta 3. (458 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
	IL36G	Interleukin-1. (170 aa)
	NFATC1	RHD domain-containing protein. (672 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	GPX1	Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (200 aa)
	IL36RN	Interleukin-1. (296 aa)
	IL18	Uncharacterized protein. (408 aa)
	LOX	Lysyl oxidase. (419 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000037329	G1TC56_RABIT	ENSOCUP00000037329	ENSOCUP00000014344	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.429
ENSOCUP00000037329	IL18	ENSOCUP00000037329	ENSOCUP00000004555	TGFb_propeptide domain-containing protein.	Uncharacterized protein.	0.424
ENSOCUP00000037329	IL36A	ENSOCUP00000037329	ENSOCUP00000012884	TGFb_propeptide domain-containing protein.	Interleukin-1.	0.521
ENSOCUP00000037329	IL36G	ENSOCUP00000037329	ENSOCUP00000005756	TGFb_propeptide domain-containing protein.	Interleukin-1.	0.519
ENSOCUP00000037329	IL36RN	ENSOCUP00000037329	ENSOCUP00000004612	TGFb_propeptide domain-containing protein.	Interleukin-1.	0.521
ENSOCUP00000037329	IL37	ENSOCUP00000037329	ENSOCUP00000023161	TGFb_propeptide domain-containing protein.	Interleukin-1.	0.541
ENSOCUP00000037329	IL6	ENSOCUP00000037329	ENSOCUP00000017266	TGFb_propeptide domain-containing protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.818
ENSOCUP00000037329	JUN	ENSOCUP00000037329	ENSOCUP00000040325	TGFb_propeptide domain-containing protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.606
ENSOCUP00000037329	LOC103345451	ENSOCUP00000037329	ENSOCUP00000031740	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.419
ENSOCUP00000037329	LOX	ENSOCUP00000037329	ENSOCUP00000044224	TGFb_propeptide domain-containing protein.	Lysyl oxidase.	0.511
ENSOCUP00000037329	NFE2L2	ENSOCUP00000037329	ENSOCUP00000026975	TGFb_propeptide domain-containing protein.	Nuclear factor, erythroid 2 like 2.	0.416
ENSOCUP00000037329	PPARG	ENSOCUP00000037329	ENSOCUP00000043929	TGFb_propeptide domain-containing protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.681
ENSOCUP00000037329	PTGS2	ENSOCUP00000037329	ENSOCUP00000014415	TGFb_propeptide domain-containing protein.	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]	0.656
ENSOCUP00000037329	RUNX2	ENSOCUP00000037329	ENSOCUP00000010093	TGFb_propeptide domain-containing protein.	RUNX family transcription factor 2.	0.653
ENSOCUP00000037329	SPARC	ENSOCUP00000037329	ENSOCUP00000010426	TGFb_propeptide domain-containing protein.	SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family.	0.442
ENSOCUP00000037329	SPP1	ENSOCUP00000037329	ENSOCUP00000021885	TGFb_propeptide domain-containing protein.	Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family.	0.654
ENSOCUP00000037329	TGFB3	ENSOCUP00000037329	ENSOCUP00000009817	TGFb_propeptide domain-containing protein.	Transforming growth factor beta 3.	0.482
ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000044284	G1TC56_RABIT	ENSOCUP00000044284	ENSOCUP00000014344	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.543