(64 nodes) (2021) Obesity Impairs Embryonic Myogenesis by Enhancing BMP Signaling within the Dermomyotome. network (Oryctolagus cuniculus)

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Predicted Interactions

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Your Input:
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	ENO2	Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family. (434 aa)
	MEOX1	Mesenchyme homeobox 1. (254 aa)
	ACVR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
	MYF6	Myogenic factor 6. (242 aa)
	HEYL	Hes related family bHLH transcription factor with YRPW motif like. (301 aa)
	PDGFRA	Protein kinase domain-containing protein. (773 aa)
	RGMA	Repulsive guidance molecule BMP co-receptor a. (325 aa)
	SMAD5	Mothers against decapentaplegic homolog. (465 aa)
	DLK1	Delta like non-canonical Notch ligand 1. (497 aa)
	EBF2	EBF transcription factor 2. (609 aa)
	PPM1A	Protein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF- beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). (385 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
	USP15	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (997 aa)
	HIF1A	Uncharacterized protein. (851 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	TPM2	Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. (352 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
	NOTCH2	Notch receptor 2. (2481 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (860 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (499 aa)
	PDCD4	Programmed cell death 4. (491 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	MYL3	Myosin light chain 3. (327 aa)
	CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (360 aa)
	BMP1	Metalloendopeptidase. (984 aa)
	MYL2	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] (232 aa)
	TBX6	T-box transcription factor 6. (488 aa)
	SMAD3	SMAD family member 3. (230 aa)
	ENO3	Beta-enolase. (352 aa)
	MYF5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
	EN1	Homeobox protein engrailed-like. (278 aa)
	BMP7	TGF_BETA_2 domain-containing protein. (170 aa)
	MYH7	Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
	ID2	Inhibitor of DNA binding 2. (109 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
	NOTO	Notochord homeobox. (248 aa)
	LGALS1	Galectin. (134 aa)
	MEOX2	Mesenchyme homeobox 2. (303 aa)
	MEF2A	Myocyte enhancer factor 2A. (511 aa)
	CEBPB	CCAAT enhancer binding protein beta. (353 aa)
	TWIST2	Twist family bHLH transcription factor 2. (160 aa)
	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform type 2. (200 aa)
	USP9X	Ubiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2575 aa)
	PAX3	Paired box 3. (484 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (452 aa)
	ACVR2A	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1228 aa)
	PGK1	Phosphoglycerate kinase. (417 aa)
	SIX1	SIX homeobox 1. (284 aa)
	TPM1	Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (326 aa)
	MEF2D	Myocyte enhancer factor 2D. (517 aa)
	MYOG	Myogenin. (225 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	BMP4	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
	TNNI1	Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (187 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (622 aa)
	ACTA2	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (471 aa)
	ACTC1	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
	PAX7	Paired box 7. (476 aa)
	CTDSPL2	CTD small phosphatase like 2. (450 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA2	MYH7	ENSOCUP00000007086	ENSOCUP00000021291	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.578
ACTA2	MYL2	ENSOCUP00000007086	ENSOCUP00000028408	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...]	0.586
ACTA2	MYL3	ENSOCUP00000007086	ENSOCUP00000029317	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin light chain 3.	0.421
ACTA2	MYLPF	ENSOCUP00000007086	ENSOCUP00000015491	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin regulatory light chain 2, skeletal muscle isoform type 2.	0.590
ACTA2	PDGFRA	ENSOCUP00000007086	ENSOCUP00000000224	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Protein kinase domain-containing protein.	0.633
ACTA2	SMAD2	ENSOCUP00000007086	ENSOCUP00000009717	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Mothers against decapentaplegic homolog.	0.497
ACTA2	SMAD3	ENSOCUP00000007086	ENSOCUP00000027151	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	SMAD family member 3.	0.493
ACTA2	TGFB2	ENSOCUP00000007086	ENSOCUP00000004578	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.466
ACTA2	TGFBR1	ENSOCUP00000007086	ENSOCUP00000035624	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.589
ACTA2	TNNI1	ENSOCUP00000007086	ENSOCUP00000008977	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	0.404
ACTA2	TPM1	ENSOCUP00000007086	ENSOCUP00000012137	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family.	0.648
ACTA2	TPM2	ENSOCUP00000007086	ENSOCUP00000039817	Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.	0.766
ACTC1	ENO3	ENSOCUP00000006542	ENSOCUP00000025169	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Beta-enolase.	0.418
ACTC1	MEF2C	ENSOCUP00000006542	ENSOCUP00000047636	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myocyte enhancer factor 2C.	0.574
ACTC1	MYF5	ENSOCUP00000006542	ENSOCUP00000023250	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.533
ACTC1	MYH7	ENSOCUP00000006542	ENSOCUP00000021291	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.887
ACTC1	MYL2	ENSOCUP00000006542	ENSOCUP00000028408	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...]	0.979
ACTC1	MYL3	ENSOCUP00000006542	ENSOCUP00000029317	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin light chain 3.	0.771
ACTC1	MYLPF	ENSOCUP00000006542	ENSOCUP00000015491	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin regulatory light chain 2, skeletal muscle isoform type 2.	0.791
ACTC1	MYOG	ENSOCUP00000006542	ENSOCUP00000009928	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myogenin.	0.658