STRINGSTRING
MT1B MT1B CUL1 CUL1 LOC103350073 LOC103350073 CFL2 CFL2 CUL4A CUL4A CUL5 CUL5 MYC MYC CUL2 CUL2 MT4 MT4 BRK1 BRK1 CUL3 CUL3 NCKAP1 NCKAP1 CUL4B CUL4B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MT1BMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (56 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
LOC103350073Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (195 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
MT4Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
NCKAP1NCK associated protein 1. (1134 aa)
CUL4BCullin 4B; Belongs to the cullin family. (901 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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