node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACE2 | ADAM17 | ENSOCUP00000015275 | ENSOCUP00000009023 | Angiotensin-converting enzyme. | ADAM metallopeptidase domain 17. | 0.775 |
ACE2 | ENSOCUP00000037329 | ENSOCUP00000015275 | ENSOCUP00000037329 | Angiotensin-converting enzyme. | TGFb_propeptide domain-containing protein. | 0.582 |
ACE2 | ENSOCUP00000044284 | ENSOCUP00000015275 | ENSOCUP00000044284 | Angiotensin-converting enzyme. | TGFb_propeptide domain-containing protein. | 0.582 |
ACE2 | G1TC56_RABIT | ENSOCUP00000015275 | ENSOCUP00000014344 | Angiotensin-converting enzyme. | TGFb_propeptide domain-containing protein. | 0.569 |
ACE2 | INS | ENSOCUP00000015275 | ENSOCUP00000020463 | Angiotensin-converting enzyme. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.798 |
ACE2 | LOC103345451 | ENSOCUP00000015275 | ENSOCUP00000031740 | Angiotensin-converting enzyme. | TGFb_propeptide domain-containing protein. | 0.582 |
ACE2 | NR3C2 | ENSOCUP00000015275 | ENSOCUP00000002724 | Angiotensin-converting enzyme. | Nuclear receptor subfamily 3 group C member 2. | 0.779 |
ACE2 | NTS | ENSOCUP00000015275 | ENSOCUP00000008901 | Angiotensin-converting enzyme. | Neurotensin. | 0.550 |
ACE2 | PPARG | ENSOCUP00000015275 | ENSOCUP00000043929 | Angiotensin-converting enzyme. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.605 |
ADAM17 | ACE2 | ENSOCUP00000009023 | ENSOCUP00000015275 | ADAM metallopeptidase domain 17. | Angiotensin-converting enzyme. | 0.775 |
ARNT | INS | ENSOCUP00000037075 | ENSOCUP00000020463 | Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.537 |
ARNT | NFIA | ENSOCUP00000037075 | ENSOCUP00000005106 | Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...] | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. | 0.418 |
ARNT | NFIB | ENSOCUP00000037075 | ENSOCUP00000032946 | Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...] | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. | 0.418 |
ARNT | PPARG | ENSOCUP00000037075 | ENSOCUP00000043929 | Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...] | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.509 |
ENSOCUP00000037329 | ACE2 | ENSOCUP00000037329 | ENSOCUP00000015275 | TGFb_propeptide domain-containing protein. | Angiotensin-converting enzyme. | 0.582 |
ENSOCUP00000037329 | ENSOCUP00000044284 | ENSOCUP00000037329 | ENSOCUP00000044284 | TGFb_propeptide domain-containing protein. | TGFb_propeptide domain-containing protein. | 0.412 |
ENSOCUP00000037329 | G1TC56_RABIT | ENSOCUP00000037329 | ENSOCUP00000014344 | TGFb_propeptide domain-containing protein. | TGFb_propeptide domain-containing protein. | 0.429 |
ENSOCUP00000037329 | INS | ENSOCUP00000037329 | ENSOCUP00000020463 | TGFb_propeptide domain-containing protein. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.744 |
ENSOCUP00000037329 | LOC103345451 | ENSOCUP00000037329 | ENSOCUP00000031740 | TGFb_propeptide domain-containing protein. | TGFb_propeptide domain-containing protein. | 0.419 |
ENSOCUP00000037329 | NFE2L2 | ENSOCUP00000037329 | ENSOCUP00000026975 | TGFb_propeptide domain-containing protein. | Nuclear factor, erythroid 2 like 2. | 0.416 |