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RTN2 RTN2 PFN1 PFN1 CCNF CCNF VCP VCP C9orf72 C9orf72 REEP1 REEP1 SPG7 SPG7 NIPA1 NIPA1 ALS2 ALS2 NAMPT NAMPT PLP1 PLP1 DCTN1 DCTN1 WASHC5 WASHC5 VAPB VAPB UBQLN2 UBQLN2 ATXN2 ATXN2 SOD1 SOD1 KIF5A KIF5A SARM1 SARM1 FUS FUS NGF NGF PNPLA6 PNPLA6 GJC2 GJC2 STMN2 STMN2 SPAST SPAST SLC52A3 SLC52A3 FIG4 FIG4 FA2H FA2H CYP7B1 CYP7B1 TBK1 TBK1 AR AR NMNAT2 NMNAT2 GAPDH GAPDH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RTN2Reticulon. (499 aa)
PFN1Profilin; Belongs to the profilin family. (104 aa)
CCNFCyclin F; Belongs to the cyclin family. (779 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
REEP1Receptor expression-enhancing protein. (380 aa)
SPG7SPG7 matrix AAA peptidase subunit, paraplegin. (766 aa)
NIPA1NIPA magnesium transporter 1. (254 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1650 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
PLP1Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. (357 aa)
DCTN1CAP-Gly domain-containing protein. (1265 aa)
WASHC5WASH complex subunit 5. (1159 aa)
VAPBVAMP associated protein B and C. (259 aa)
UBQLN2Ubiquilin 2. (614 aa)
ATXN2Ataxin 2. (1136 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1032 aa)
SARM1Sterile alpha and TIR motif containing 1. (703 aa)
FUSFUS RNA binding protein. (517 aa)
NGFNerve growth factor. (157 aa)
PNPLA6Patatin like phospholipase domain containing 6. (1396 aa)
GJC2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (231 aa)
STMN2Stathmin; Belongs to the stathmin family. (184 aa)
SPASTSpastin; Belongs to the AAA ATPase family. (549 aa)
SLC52A3Uncharacterized protein. (585 aa)
FIG4FIG4 phosphoinositide 5-phosphatase. (907 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (371 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (588 aa)
TBK1TANK binding kinase 1. (836 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (925 aa)
NMNAT2CTP_transf_like domain-containing protein. (543 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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