26 items (Oryctolagus cuniculus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	SEC31A	SEC31 homolog A, COPII coat complex component. (1263 aa)
	KBTBD8	Uncharacterized protein. (153 aa)
	SKP1	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	KLHL41	Kelch like family member 41. (606 aa)
	USP9X	Ubiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2575 aa)
	DET1	Uncharacterized protein. (553 aa)
	UBE2M	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa)
	KLHL1	Kelch like family member 1. (746 aa)
	KLHL25	Kelch like family member 25. (734 aa)
	SEC13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (468 aa)
	KLHL12	Kelch like family member 12. (851 aa)
	UBA1	Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity). (1058 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (463 aa)
	PEF1	Penta-EF-hand domain containing 1. (277 aa)
	USP19	Ubiquitin specific peptidase 19. (1379 aa)
	CAND1	Cullin associated and neddylation dissociated 1. (1207 aa)
	USP25	Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1152 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	TCOF1	Treacle ribosome biogenesis factor 1. (1492 aa)
	NEDD8	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (775 aa)
	CAND2	Cullin associated and neddylation dissociated 2 (putative). (1267 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
	SVIP	Uncharacterized protein. (231 aa)
	VCL	Vinculin. (1241 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (771 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAND1	CUL1	ENSOCUP00000004347	ENSOCUP00000002198	Cullin associated and neddylation dissociated 1.	Cullin 1; Belongs to the cullin family.	0.999
CAND1	CUL3	ENSOCUP00000004347	ENSOCUP00000031324	Cullin associated and neddylation dissociated 1.	Cullin 3; Belongs to the cullin family.	0.946
CAND1	KLHL12	ENSOCUP00000004347	ENSOCUP00000007958	Cullin associated and neddylation dissociated 1.	Kelch like family member 12.	0.517
CAND1	NEDD8	ENSOCUP00000004347	ENSOCUP00000002526	Cullin associated and neddylation dissociated 1.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.943
CAND1	SKP1	ENSOCUP00000004347	ENSOCUP00000020468	Cullin associated and neddylation dissociated 1.	Uncharacterized protein; Belongs to the SKP1 family.	0.849
CAND1	UBA1	ENSOCUP00000004347	ENSOCUP00000007237	Cullin associated and neddylation dissociated 1.	Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity).	0.568
CAND1	UBA3	ENSOCUP00000004347	ENSOCUP00000007065	Cullin associated and neddylation dissociated 1.	Ubiquitin like modifier activating enzyme 3.	0.672
CAND1	UBE2M	ENSOCUP00000004347	ENSOCUP00000014290	Cullin associated and neddylation dissociated 1.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.827
CAND2	CUL1	ENSOCUP00000048764	ENSOCUP00000002198	Cullin associated and neddylation dissociated 2 (putative).	Cullin 1; Belongs to the cullin family.	0.949
CAND2	CUL3	ENSOCUP00000048764	ENSOCUP00000031324	Cullin associated and neddylation dissociated 2 (putative).	Cullin 3; Belongs to the cullin family.	0.879
CAND2	NEDD8	ENSOCUP00000048764	ENSOCUP00000002526	Cullin associated and neddylation dissociated 2 (putative).	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.790
CAND2	SKP1	ENSOCUP00000048764	ENSOCUP00000020468	Cullin associated and neddylation dissociated 2 (putative).	Uncharacterized protein; Belongs to the SKP1 family.	0.677
CAND2	UBE2M	ENSOCUP00000048764	ENSOCUP00000014290	Cullin associated and neddylation dissociated 2 (putative).	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.550
CUL1	CAND1	ENSOCUP00000002198	ENSOCUP00000004347	Cullin 1; Belongs to the cullin family.	Cullin associated and neddylation dissociated 1.	0.999
CUL1	CAND2	ENSOCUP00000002198	ENSOCUP00000048764	Cullin 1; Belongs to the cullin family.	Cullin associated and neddylation dissociated 2 (putative).	0.949
CUL1	CUL3	ENSOCUP00000002198	ENSOCUP00000031324	Cullin 1; Belongs to the cullin family.	Cullin 3; Belongs to the cullin family.	0.887
CUL1	DET1	ENSOCUP00000002198	ENSOCUP00000015075	Cullin 1; Belongs to the cullin family.	Uncharacterized protein.	0.456
CUL1	GAPDH	ENSOCUP00000002198	ENSOCUP00000044112	Cullin 1; Belongs to the cullin family.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.538
CUL1	KBTBD8	ENSOCUP00000002198	ENSOCUP00000025925	Cullin 1; Belongs to the cullin family.	Uncharacterized protein.	0.589
CUL1	KLHL1	ENSOCUP00000002198	ENSOCUP00000013034	Cullin 1; Belongs to the cullin family.	Kelch like family member 1.	0.469