STRINGSTRING
MYF5 MYF5 FGF2 FGF2 GPC3 GPC3 RABIF RABIF SRF SRF CSPG4 CSPG4 PAX7 PAX7 SDC3 SDC3 FBN2 FBN2 CFL2 CFL2 RAC1 RAC1 TLN1 TLN1 EGFR EGFR ERBB2 ERBB2 MYOG MYOG MSTN MSTN TLN2 TLN2 RHOA RHOA FOXO1 FOXO1 ALB ALB LOC100345682 LOC100345682 PRKCA PRKCA CDC42-2 CDC42-2 PXN PXN VCL VCL PROX1 PROX1 GAPDH GAPDH CDC42 CDC42 EGF EGF TIAM1 TIAM1 PAX3 PAX3 TWIST2 TWIST2 SDC1 SDC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
RABIFRAB interacting factor. (123 aa)
SRFSerum response factor. (685 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2310 aa)
PAX7Paired box 7. (476 aa)
SDC3Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (435 aa)
FBN2Fibrillin 2. (2912 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (195 aa)
RAC1Rac family small GTPase 1. (199 aa)
TLN1Talin 1. (2558 aa)
EGFRReceptor protein-tyrosine kinase. (1193 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MYOGMyogenin. (225 aa)
MSTNMyostatin. (375 aa)
TLN2Talin 2. (2536 aa)
RHOARas homolog family member A. (193 aa)
FOXO1Fork-head domain-containing protein. (613 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
LOC100345682Uncharacterized protein. (1724 aa)
PRKCAProtein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regul [...] (664 aa)
CDC42-2Uncharacterized protein. (222 aa)
PXNPaxillin. (1072 aa)
VCLVinculin. (1241 aa)
PROX1Prospero homeobox 1. (737 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
CDC42Uncharacterized protein. (191 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1592 aa)
PAX3Paired box 3. (484 aa)
TWIST2Twist family bHLH transcription factor 2. (160 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (401 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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