STRINGSTRING
FGF5 FGF5 IL6 IL6 HYAL3 HYAL3 COL4A5 COL4A5 LOC100337977 LOC100337977 LOC103345451 LOC103345451 ENSOCUP00000037329 ENSOCUP00000037329 LOX LOX ENSOCUP00000044284 ENSOCUP00000044284 TGFB3 TGFB3 VIM VIM HYAL1 HYAL1 HYAL2 HYAL2 CCN2 CCN2 CCL2 CCL2 G1TC56_RABIT G1TC56_RABIT ALB ALB MMP3 MMP3 HYAL4 HYAL4 COL1A1 COL1A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
HYAL3Hyaluronidase. (492 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
LOC100337977Hyaluronidase. (480 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
LOXLysyl oxidase. (419 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
HYAL1Hyaluronidase. (497 aa)
HYAL2Hyaluronidase. (475 aa)
CCN2Cellular communication network factor 2. (437 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
G1TC56_RABITTGFb_propeptide domain-containing protein. (168 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
MMP3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (478 aa)
HYAL4Hyaluronidase. (484 aa)
COL1A1Collagen alpha-1(I) chain. (1348 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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