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MMP13 MMP13 CD44 CD44 CDC42 CDC42 ENSOCUP00000044284 ENSOCUP00000044284 GAPDH GAPDH ENSOCUP00000037329 ENSOCUP00000037329 TWF1 TWF1 IGFBP2 IGFBP2 CTNNB1 CTNNB1 CD34 CD34 LOC103345451 LOC103345451 CDC42-2 CDC42-2 TOB2 TOB2 MMP9 MMP9 MYF5 MYF5 ABLIM1 ABLIM1 PXDN PXDN INS INS ADAMTS2 ADAMTS2 HPRT1 HPRT1 IL6 IL6 SOX11 SOX11 PAX3 PAX3 G1TC56_RABIT G1TC56_RABIT ALB ALB RHO RHO SCAI SCAI FOXJ3 FOXJ3 MYOG MYOG FOXJ1 FOXJ1 SMAD2 SMAD2 STAT3 STAT3 ACKR3 ACKR3 ERBB2 ERBB2 MMP12 MMP12 PAX7 PAX7 PXDNL PXDNL ADAMTS5 ADAMTS5 CXCR4 CXCR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP13Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (471 aa)
CD44CD44 molecule (Indian blood group). (761 aa)
CDC42Uncharacterized protein. (191 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
TWF1Twinfilin actin binding protein 1. (498 aa)
IGFBP2IGFBP N-terminal domain-containing protein. (442 aa)
CTNNB1Catenin beta 1. (741 aa)
CD34CD34 molecule. (415 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
CDC42-2Uncharacterized protein. (222 aa)
TOB2Transducer of ERBB2, 2. (345 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
ABLIM1Actin binding LIM protein 1. (831 aa)
PXDNPeroxidasin. (1411 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2. (1174 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
SOX11Transcription factor SOX. (446 aa)
PAX3Paired box 3. (484 aa)
G1TC56_RABITTGFb_propeptide domain-containing protein. (168 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
RHORhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (355 aa)
SCAIProtein SCAI; Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. (606 aa)
FOXJ3Forkhead box J3. (563 aa)
MYOGMyogenin. (225 aa)
FOXJ1Forkhead box J1. (421 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (336 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MMP12Macrophage metalloelastase; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity). Belongs to the peptidase M10A family. (464 aa)
PAX7Paired box 7. (476 aa)
PXDNLPeroxidasin like. (1467 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (931 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (366 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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