node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABL1 | BCR | ENSOCUP00000038489 | ENSOCUP00000027066 | Tyrosine-protein kinase. | BCR activator of RhoGEF and GTPase. | 0.948 |
ABL1 | IKZF1 | ENSOCUP00000038489 | ENSOCUP00000012401 | Tyrosine-protein kinase. | IKAROS family zinc finger 1. | 0.566 |
ABL1 | PAX5 | ENSOCUP00000038489 | ENSOCUP00000010574 | Tyrosine-protein kinase. | Paired box 5. | 0.449 |
ABL1 | TP53 | ENSOCUP00000038489 | ENSOCUP00000000989 | Tyrosine-protein kinase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.688 |
BCR | ABL1 | ENSOCUP00000027066 | ENSOCUP00000038489 | BCR activator of RhoGEF and GTPase. | Tyrosine-protein kinase. | 0.948 |
CD80 | IL6 | ENSOCUP00000008197 | ENSOCUP00000017266 | T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.877 |
EBF1 | IKZF1 | ENSOCUP00000007763 | ENSOCUP00000012401 | EBF transcription factor 1. | IKAROS family zinc finger 1. | 0.637 |
EBF1 | PAX5 | ENSOCUP00000007763 | ENSOCUP00000010574 | EBF transcription factor 1. | Paired box 5. | 0.831 |
HIF1A | IL6 | ENSOCUP00000041090 | ENSOCUP00000017266 | Uncharacterized protein. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.796 |
HIF1A | RORA | ENSOCUP00000041090 | ENSOCUP00000032126 | Uncharacterized protein. | RAR related orphan receptor A. | 0.447 |
HIF1A | TP53 | ENSOCUP00000041090 | ENSOCUP00000000989 | Uncharacterized protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.916 |
IKZF1 | ABL1 | ENSOCUP00000012401 | ENSOCUP00000038489 | IKAROS family zinc finger 1. | Tyrosine-protein kinase. | 0.566 |
IKZF1 | EBF1 | ENSOCUP00000012401 | ENSOCUP00000007763 | IKAROS family zinc finger 1. | EBF transcription factor 1. | 0.637 |
IKZF1 | PAX5 | ENSOCUP00000012401 | ENSOCUP00000010574 | IKAROS family zinc finger 1. | Paired box 5. | 0.825 |
IKZF1 | TP53 | ENSOCUP00000012401 | ENSOCUP00000000989 | IKAROS family zinc finger 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.440 |
IL6 | CD80 | ENSOCUP00000017266 | ENSOCUP00000008197 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor. | 0.877 |
IL6 | HIF1A | ENSOCUP00000017266 | ENSOCUP00000041090 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Uncharacterized protein. | 0.796 |
IL6 | MX1 | ENSOCUP00000017266 | ENSOCUP00000016943 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.725 |
IL6 | SHH | ENSOCUP00000017266 | ENSOCUP00000014488 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.444 |
IL6 | TP53 | ENSOCUP00000017266 | ENSOCUP00000000989 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.728 |