STRINGSTRING
EBF1 EBF1 XRCC5 XRCC5 TP53 TP53 HIF1A HIF1A ABL1 ABL1 RORA RORA LMO1 LMO1 BCR BCR IL6 IL6 MX1 MX1 ZBTB10 ZBTB10 SHH SHH IKZF1 IKZF1 PAX5 PAX5 MYB MYB CD80 CD80
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EBF1EBF transcription factor 1. (591 aa)
XRCC5X-ray repair cross complementing 5. (733 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
HIF1AUncharacterized protein. (851 aa)
ABL1Tyrosine-protein kinase. (1118 aa)
RORARAR related orphan receptor A. (512 aa)
LMO1LIM domain only 1. (227 aa)
BCRBCR activator of RhoGEF and GTPase. (1192 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
MX1Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (697 aa)
ZBTB10Zinc finger and BTB domain containing 10. (874 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
IKZF1IKAROS family zinc finger 1. (515 aa)
PAX5Paired box 5. (371 aa)
MYBMYB proto-oncogene, transcription factor. (758 aa)
CD80T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor. (299 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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