STRINGSTRING
SMAD2 SMAD2 BNIP3 BNIP3 CKMT1A CKMT1A H2BC21 H2BC21 SMAD4 SMAD4 TGFB2 TGFB2 GLB1 GLB1 CNMD CNMD SMAD6 SMAD6 H2BU1 H2BU1 PAX7 PAX7 INHBE INHBE H2BC3 H2BC3 GDF6 GDF6 CKMT2 CKMT2 GLB1L3 GLB1L3 TGFB3 TGFB3 CDKN2B CDKN2B MSTN MSTN HOXB13 HOXB13 MTOR MTOR TRIM63 TRIM63 RUNX1 RUNX1 LOC100348835 LOC100348835 LOC100343938 LOC100343938 FBXO21 FBXO21 LOC100350750 LOC100350750 DMD DMD BECN1 BECN1 ALB ALB SMURF1 SMURF1 ACVR2A ACVR2A BMPR1A BMPR1A ACVR1B ACVR1B LOC100342379 LOC100342379 HDAC4 HDAC4 LOC100353468 LOC100353468 H2BC18 H2BC18 G1TLP0_RABIT G1TLP0_RABIT H2BE1 H2BE1 BMP7 BMP7 GDF11 GDF11 G1U1K0_RABIT G1U1K0_RABIT ASB2 ASB2 SMAD3 SMAD3 SMAD9 SMAD9 CTSV CTSV VCL VCL FBXO32 FBXO32 NOG NOG AR AR GAPDH GAPDH CKB CKB GLB1L2 GLB1L2 LOC103345097 LOC103345097
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD2Mothers against decapentaplegic homolog. (467 aa)
BNIP3BCL2 interacting protein 3. (218 aa)
CKMT1ACreatine kinase, mitochondrial 1A (Predicted); Belongs to the ATP:guanido phosphotransferase family. (417 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GLB1Beta-galactosidase. (843 aa)
CNMDLeukocyte cell-derived chemotaxin 1; Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity); Belongs to the chondrom [...] (310 aa)
SMAD6MH2 domain-containing protein. (220 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (67 aa)
PAX7Paired box 7. (476 aa)
INHBEInhibin subunit beta E. (352 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
GDF6Growth differentiation factor 6. (427 aa)
CKMT2Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). (419 aa)
GLB1L3Beta-galactosidase. (654 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
MSTNMyostatin. (375 aa)
HOXB13Homeobox B13. (284 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
TRIM63Tripartite motif containing 63. (400 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (466 aa)
LOC100348835Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC100343938Histone H2B; Belongs to the histone H2B family. (126 aa)
FBXO21F-box protein 21. (710 aa)
LOC100350750Histone H2B; Belongs to the histone H2B family. (127 aa)
DMDUncharacterized protein. (956 aa)
BECN1Uncharacterized protein. (448 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
SMURF1E3 ubiquitin-protein ligase. (737 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (474 aa)
LOC100342379Histone H2B; Belongs to the histone H2B family. (126 aa)
HDAC4Hist_deacetyl domain-containing protein. (279 aa)
LOC100353468Histone domain-containing protein; Belongs to the histone H2B family. (133 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (133 aa)
G1TLP0_RABITHistone H2B; Belongs to the histone H2B family. (161 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (123 aa)
BMP7TGF_BETA_2 domain-containing protein. (170 aa)
GDF11Growth differentiation factor 11. (395 aa)
G1U1K0_RABITHistone domain-containing protein; Belongs to the histone H2B family. (125 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (603 aa)
SMAD3SMAD family member 3. (230 aa)
SMAD9Mothers against decapentaplegic homolog. (441 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (356 aa)
VCLVinculin. (1241 aa)
FBXO32F-box protein 32. (364 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (925 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
CKBCreatine kinase B-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. (425 aa)
GLB1L2Beta-galactosidase. (699 aa)
LOC103345097Beta-galactosidase. (683 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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