node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADIPOQ | CD4 | ENSOCUP00000020897 | ENSOCUP00000030708 | C1q domain-containing protein. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.400 |
ADIPOQ | CD68 | ENSOCUP00000020897 | ENSOCUP00000008945 | C1q domain-containing protein. | CD68 molecule. | 0.553 |
ADIPOQ | IL21 | ENSOCUP00000020897 | ENSOCUP00000013142 | C1q domain-containing protein. | Interleukin; Belongs to the IL-15/IL-21 family. | 0.649 |
ADIPOQ | SPP1 | ENSOCUP00000020897 | ENSOCUP00000021885 | C1q domain-containing protein. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.542 |
ANO5 | SGCA | ENSOCUP00000046886 | ENSOCUP00000018374 | Anoctamin. | Alpha-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. | 0.657 |
CD4 | ADIPOQ | ENSOCUP00000030708 | ENSOCUP00000020897 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | C1q domain-containing protein. | 0.400 |
CD4 | CD68 | ENSOCUP00000030708 | ENSOCUP00000008945 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | CD68 molecule. | 0.907 |
CD4 | HAND2 | ENSOCUP00000030708 | ENSOCUP00000013968 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | BHLH domain-containing protein. | 0.429 |
CD4 | IL21 | ENSOCUP00000030708 | ENSOCUP00000013142 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Interleukin; Belongs to the IL-15/IL-21 family. | 0.855 |
CD4 | JCHAIN | ENSOCUP00000030708 | ENSOCUP00000023316 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Immunoglobulin J chain; Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component. | 0.512 |
CD4 | SPP1 | ENSOCUP00000030708 | ENSOCUP00000021885 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.450 |
CD4 | TGFB2 | ENSOCUP00000030708 | ENSOCUP00000004578 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.408 |
CD68 | ADIPOQ | ENSOCUP00000008945 | ENSOCUP00000020897 | CD68 molecule. | C1q domain-containing protein. | 0.553 |
CD68 | CD4 | ENSOCUP00000008945 | ENSOCUP00000030708 | CD68 molecule. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.907 |
CD68 | COL1A1 | ENSOCUP00000008945 | ENSOCUP00000011096 | CD68 molecule. | Collagen alpha-1(I) chain. | 0.583 |
CD68 | IL21 | ENSOCUP00000008945 | ENSOCUP00000013142 | CD68 molecule. | Interleukin; Belongs to the IL-15/IL-21 family. | 0.700 |
CD68 | PDGFRA | ENSOCUP00000008945 | ENSOCUP00000000224 | CD68 molecule. | Protein kinase domain-containing protein. | 0.468 |
CD68 | SPP1 | ENSOCUP00000008945 | ENSOCUP00000021885 | CD68 molecule. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.610 |
COL1A1 | CD68 | ENSOCUP00000011096 | ENSOCUP00000008945 | Collagen alpha-1(I) chain. | CD68 molecule. | 0.583 |
COL1A1 | LUM | ENSOCUP00000011096 | ENSOCUP00000004852 | Collagen alpha-1(I) chain. | Lumican. | 0.872 |