11 items (Oryctolagus cuniculus) - STRING interaction network

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	FGF2	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	HGF	Heptapoietin A light chain; HPTA is an acidic heparin-binding growth factor for hepatocytes. (761 aa)
	ACAN	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2167 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
	G1TC56_RABIT	TGFb_propeptide domain-containing protein. (168 aa)
	TGFB3	Transforming growth factor beta 3. (458 aa)
	MKX	Mohawk homeobox. (357 aa)
	CCN2	Cellular communication network factor 2. (437 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	CCN2	ENSOCUP00000024918	ENSOCUP00000002454	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Cellular communication network factor 2.	0.603
ACAN	ENSOCUP00000037329	ENSOCUP00000024918	ENSOCUP00000037329	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	TGFb_propeptide domain-containing protein.	0.675
ACAN	ENSOCUP00000044284	ENSOCUP00000024918	ENSOCUP00000044284	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	TGFb_propeptide domain-containing protein.	0.675
ACAN	FGF2	ENSOCUP00000024918	ENSOCUP00000000416	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family.	0.700
ACAN	G1TC56_RABIT	ENSOCUP00000024918	ENSOCUP00000014344	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	TGFb_propeptide domain-containing protein.	0.648
ACAN	IGF1	ENSOCUP00000024918	ENSOCUP00000021389	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.726
ACAN	LOC103345451	ENSOCUP00000024918	ENSOCUP00000031740	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	TGFb_propeptide domain-containing protein.	0.675
ACAN	MKX	ENSOCUP00000024918	ENSOCUP00000009176	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Mohawk homeobox.	0.500
ACAN	TGFB3	ENSOCUP00000024918	ENSOCUP00000009817	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Transforming growth factor beta 3.	0.684
CCN2	ACAN	ENSOCUP00000002454	ENSOCUP00000024918	Cellular communication network factor 2.	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.603
CCN2	ENSOCUP00000037329	ENSOCUP00000002454	ENSOCUP00000037329	Cellular communication network factor 2.	TGFb_propeptide domain-containing protein.	0.858
CCN2	ENSOCUP00000044284	ENSOCUP00000002454	ENSOCUP00000044284	Cellular communication network factor 2.	TGFb_propeptide domain-containing protein.	0.858
CCN2	FGF2	ENSOCUP00000002454	ENSOCUP00000000416	Cellular communication network factor 2.	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family.	0.706
CCN2	G1TC56_RABIT	ENSOCUP00000002454	ENSOCUP00000014344	Cellular communication network factor 2.	TGFb_propeptide domain-containing protein.	0.841
CCN2	HGF	ENSOCUP00000002454	ENSOCUP00000030750	Cellular communication network factor 2.	Heptapoietin A light chain; HPTA is an acidic heparin-binding growth factor for hepatocytes.	0.655
CCN2	IGF1	ENSOCUP00000002454	ENSOCUP00000021389	Cellular communication network factor 2.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.665
CCN2	LOC103345451	ENSOCUP00000002454	ENSOCUP00000031740	Cellular communication network factor 2.	TGFb_propeptide domain-containing protein.	0.858
CCN2	TGFB3	ENSOCUP00000002454	ENSOCUP00000009817	Cellular communication network factor 2.	Transforming growth factor beta 3.	0.567
ENSOCUP00000037329	ACAN	ENSOCUP00000037329	ENSOCUP00000024918	TGFb_propeptide domain-containing protein.	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.675
ENSOCUP00000037329	CCN2	ENSOCUP00000037329	ENSOCUP00000002454	TGFb_propeptide domain-containing protein.	Cellular communication network factor 2.	0.858