STRINGSTRING
CD4 CD4 TRAF6 TRAF6 IL1B IL1B CUL1 CUL1 HDAC4 HDAC4 TAB1 TAB1 KPNA2 KPNA2 GAPDH GAPDH CUL2 CUL2 CUL5 CUL5 CUL4A CUL4A KPNA3 KPNA3 KLHL12 KLHL12 CD69 CD69 KPNA1 KPNA1 BCL2 BCL2 KLHL13 KLHL13 CUL3 CUL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
HDAC4Hist_deacetyl domain-containing protein. (279 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
KPNA3Importin subunit alpha; Functions in nuclear protein import. (530 aa)
KLHL12Kelch like family member 12. (851 aa)
CD69CD69 molecule. (201 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
KLHL13Kelch like family member 13. (658 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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