(29 nodes) (2023) Phosphate, calcium, and vitamin D signaling, transport, and metabolism in the endometria of cyclic ewes. network (Oryctolagus cuniculus)

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	SLC20A2	Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. (725 aa)
	ATP2B3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1245 aa)
	GC	Vitamin D-binding protein; Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. (584 aa)
	FGFR1	Fibroblast growth factor receptor. (823 aa)
	ADAM10	ADAM metallopeptidase domain 10. (748 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	FGFR2	Fibroblast growth factor receptor. (894 aa)
	HGF	Heptapoietin A light chain; HPTA is an acidic heparin-binding growth factor for hepatocytes. (761 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (548 aa)
	PTHLH	Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity o [...] (220 aa)
	CYP11A1	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (589 aa)
	LOC100353077	Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa)
	KL	Klotho. (1005 aa)
	S100A12	Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] (95 aa)
	S100G	Protein S100; Belongs to the S-100 family. (138 aa)
	VDR	Vitamin D receptor. (368 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (120 aa)
	PGR	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation; Belongs to the nuclear hormone receptor family. NR3 subfamily. (930 aa)
	ADAM17	ADAM metallopeptidase domain 17. (827 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
	TRPV6	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (699 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
	PTH	Parathyroid hormone. (131 aa)
	SLC20A1	Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. (683 aa)
	FGF19	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (218 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
	CYP24A1	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (646 aa)
	YWHAZ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (252 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	ADAM17	ENSOCUP00000037667	ENSOCUP00000009023	ADAM metallopeptidase domain 10.	ADAM metallopeptidase domain 17.	0.943
ADAM10	KL	ENSOCUP00000037667	ENSOCUP00000019540	ADAM metallopeptidase domain 10.	Klotho.	0.530
ADAM17	ADAM10	ENSOCUP00000009023	ENSOCUP00000037667	ADAM metallopeptidase domain 17.	ADAM metallopeptidase domain 10.	0.943
ADAM17	KL	ENSOCUP00000009023	ENSOCUP00000019540	ADAM metallopeptidase domain 17.	Klotho.	0.531
ATP2B3	ATP2B4	ENSOCUP00000049817	ENSOCUP00000005655	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.908
ATP2B4	ATP2B3	ENSOCUP00000005655	ENSOCUP00000049817	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.908
B2M	ESR1	ENSOCUP00000014707	ENSOCUP00000004174	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.416
B2M	YWHAZ	ENSOCUP00000014707	ENSOCUP00000000636	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family.	0.723
CYP11A1	ESR1	ENSOCUP00000023976	ENSOCUP00000004174	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.503
CYP11A1	LOC100353077	ENSOCUP00000023976	ENSOCUP00000020953	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.452
CYP11A1	PGR	ENSOCUP00000023976	ENSOCUP00000012634	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.458
CYP24A1	GC	ENSOCUP00000004268	ENSOCUP00000047639	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family.	Vitamin D-binding protein; Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.	0.779
CYP24A1	KL	ENSOCUP00000004268	ENSOCUP00000019540	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family.	Klotho.	0.648
CYP24A1	LOC100353077	ENSOCUP00000004268	ENSOCUP00000020953	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.952
CYP24A1	PTH	ENSOCUP00000004268	ENSOCUP00000004740	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family.	Parathyroid hormone.	0.725
CYP24A1	S100G	ENSOCUP00000004268	ENSOCUP00000017790	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family.	Protein S100; Belongs to the S-100 family.	0.536
CYP24A1	TRPV6	ENSOCUP00000004268	ENSOCUP00000006533	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family.	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.	0.591
CYP24A1	VDR	ENSOCUP00000004268	ENSOCUP00000016485	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family.	Vitamin D receptor.	0.838
CYP27B1	GC	ENSOCUP00000028384	ENSOCUP00000047639	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Vitamin D-binding protein; Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.	0.730
CYP27B1	KL	ENSOCUP00000028384	ENSOCUP00000019540	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Klotho.	0.752