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ARNT ARNT TLR4 TLR4 CASP1 CASP1 TRAF4 TRAF4 MT1B MT1B ATOX1 ATOX1 LOX LOX ATP7B ATP7B MYD88 MYD88 CP CP CTSB CTSB DLAT DLAT LOC100358658 LOC100358658 COX17 COX17 IL1B IL1B SOD1 SOD1 MT4 MT4 ALB ALB IL21 IL21 ATP7A ATP7A CCS CCS RAC1 RAC1 CLUL1 CLUL1 LOC103350073 LOC103350073 CLU CLU CREBBP CREBBP THBS1 THBS1 BNIP3 BNIP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARNTAryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...] (739 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (418 aa)
TRAF4TNF receptor-associated factor. (470 aa)
MT1BMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (56 aa)
ATOX1Antioxidant 1 copper chaperone. (68 aa)
LOXLysyl oxidase. (419 aa)
ATP7BATPase copper transporting beta. (1465 aa)
MYD88Uncharacterized protein. (476 aa)
CPCeruloplasmin; Belongs to the multicopper oxidase family. (1098 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (456 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (655 aa)
LOC100358658Uncharacterized protein; Belongs to the peptidase C14A family. (368 aa)
COX17Cytochrome c oxidase copper chaperone COX17. (63 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
MT4Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (154 aa)
ATP7AATPase copper transporting alpha. (1499 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
RAC1Rac family small GTPase 1. (199 aa)
CLUL1Clusterin; Belongs to the clusterin family. (469 aa)
LOC103350073Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
CLUClusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (518 aa)
CREBBPCREB binding protein. (2403 aa)
THBS1Thrombospondin 1. (1171 aa)
BNIP3BCL2 interacting protein 3. (218 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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