STRINGSTRING
MYH8 MYH8 NCAM1 NCAM1 PAX7 PAX7 COL16A1 COL16A1 ACTA1 ACTA1 THBS1 THBS1 CCR2 CCR2 CCR1 CCR1 MYH4 MYH4 CCL5 CCL5 TNNT3 TNNT3 LOC100348776 LOC100348776 COL6A2 COL6A2 PDGFRA PDGFRA CD44 CD44 TNFRSF1A TNFRSF1A CDH3 CDH3 LOC100348748 LOC100348748 SEMA4A SEMA4A CDH26 CDH26 TGFBR2 TGFBR2 NKG7 NKG7 KRT18 KRT18 ASPN ASPN THBS2 THBS2 IL1B IL1B TNNT2 TNNT2 MYH1 MYH1 CCL2 CCL2 COL12A1 COL12A1 TNFRSF1B TNFRSF1B TPM1 TPM1 COL1A1 COL1A1 COL1A2 COL1A2 MYOG MYOG CTSS CTSS CD68 CD68 ACTC1 ACTC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYH8Myosin heavy chain 8; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
NCAM1Neural cell adhesion molecule 1. (1121 aa)
PAX7Paired box 7. (476 aa)
COL16A1Collagen type XVI alpha 1 chain. (1606 aa)
ACTA1Actin, alpha skeletal muscle. (369 aa)
THBS1Thrombospondin 1. (1171 aa)
CCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CCR1Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (351 aa)
MYH4Myosin-4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
CCL5C-C motif chemokine. (91 aa)
TNNT3Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (202 aa)
LOC100348776C-C motif chemokine. (93 aa)
COL6A2Uncharacterized protein. (425 aa)
PDGFRAProtein kinase domain-containing protein. (773 aa)
CD44CD44 molecule (Indian blood group). (761 aa)
TNFRSF1ATNF receptor superfamily member 1A. (472 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (1102 aa)
LOC100348748IGv domain-containing protein. (604 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (977 aa)
CDH26Uncharacterized protein. (444 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
NKG7Natural killer cell granule protein 7. (171 aa)
KRT18IF rod domain-containing protein; Belongs to the intermediate filament family. (431 aa)
ASPNAsporin. (373 aa)
THBS2Thrombospondin 2. (1170 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
TNNT2Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (341 aa)
MYH1Myosin-4; Muscle contraction. (1938 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
COL12A1Collagen alpha-1(XII) chain; Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. (3112 aa)
TNFRSF1BTNF receptor superfamily member 1B. (425 aa)
TPM1Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (326 aa)
COL1A1Collagen alpha-1(I) chain. (1348 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1364 aa)
MYOGMyogenin. (225 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (340 aa)
CD68CD68 molecule. (334 aa)
ACTC1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.