(8 nodes) (2023) Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3. network (Oryctolagus cuniculus)

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Your Input:
	MYL2	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] (232 aa)
	MYLK3	Myosin light chain kinase 3. (862 aa)
	CALM2	Uncharacterized protein; Belongs to the calmodulin family. (153 aa)
	TNNT3	Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (202 aa)
	NPPA	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (153 aa)
	CALM1	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
	CALML5	Calmodulin like 5. (149 aa)
	MYH7	Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALM1	CALM2	ENSOCUP00000010025	ENSOCUP00000048696	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Uncharacterized protein; Belongs to the calmodulin family.	0.440
CALM1	CALML5	ENSOCUP00000010025	ENSOCUP00000010863	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Calmodulin like 5.	0.938
CALM1	MYH7	ENSOCUP00000010025	ENSOCUP00000021291	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.555
CALM1	MYL2	ENSOCUP00000010025	ENSOCUP00000028408	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...]	0.627
CALM1	MYLK3	ENSOCUP00000010025	ENSOCUP00000038834	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Myosin light chain kinase 3.	0.457
CALM1	NPPA	ENSOCUP00000010025	ENSOCUP00000006321	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.574
CALM1	TNNT3	ENSOCUP00000010025	ENSOCUP00000001509	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	0.466
CALM2	CALM1	ENSOCUP00000048696	ENSOCUP00000010025	Uncharacterized protein; Belongs to the calmodulin family.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	0.440
CALM2	MYH7	ENSOCUP00000048696	ENSOCUP00000021291	Uncharacterized protein; Belongs to the calmodulin family.	Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.534
CALM2	MYLK3	ENSOCUP00000048696	ENSOCUP00000038834	Uncharacterized protein; Belongs to the calmodulin family.	Myosin light chain kinase 3.	0.448
CALM2	NPPA	ENSOCUP00000048696	ENSOCUP00000006321	Uncharacterized protein; Belongs to the calmodulin family.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.550
CALM2	TNNT3	ENSOCUP00000048696	ENSOCUP00000001509	Uncharacterized protein; Belongs to the calmodulin family.	Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	0.464
CALML5	CALM1	ENSOCUP00000010863	ENSOCUP00000010025	Calmodulin like 5.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	0.938
CALML5	MYH7	ENSOCUP00000010863	ENSOCUP00000021291	Calmodulin like 5.	Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.531
CALML5	MYLK3	ENSOCUP00000010863	ENSOCUP00000038834	Calmodulin like 5.	Myosin light chain kinase 3.	0.463
CALML5	NPPA	ENSOCUP00000010863	ENSOCUP00000006321	Calmodulin like 5.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.550
CALML5	TNNT3	ENSOCUP00000010863	ENSOCUP00000001509	Calmodulin like 5.	Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	0.465
MYH7	CALM1	ENSOCUP00000021291	ENSOCUP00000010025	Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	0.555
MYH7	CALM2	ENSOCUP00000021291	ENSOCUP00000048696	Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Uncharacterized protein; Belongs to the calmodulin family.	0.534
MYH7	CALML5	ENSOCUP00000021291	ENSOCUP00000010863	Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Calmodulin like 5.	0.531