STRINGSTRING
ACTC1 ACTC1 HNRNPC HNRNPC TP53 TP53 METTL14 METTL14 MYH4 MYH4 ITGB1 ITGB1 ACTA1 ACTA1 IGF2BP3 IGF2BP3 ALKBH5 ALKBH5 METTL5 METTL5 ASH1L ASH1L ENSOCUP00000012913 ENSOCUP00000012913 YTHDC1 YTHDC1 VIRMA VIRMA SHH SHH MYH1 MYH1 CTLA4 CTLA4 METTL16 METTL16 PRRC2A PRRC2A INS INS ZC3H13 ZC3H13 MYH7 MYH7 HNRNPA2B1 HNRNPA2B1 RBM15B RBM15B YTHDF1 YTHDF1 CD4 CD4 SPOP SPOP FTO FTO HNRNPA2B1-2 HNRNPA2B1-2 IGF2BP2 IGF2BP2 TRIM44 TRIM44 WTAP WTAP YTHDF3 YTHDF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTC1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
HNRNPCHeterogeneous nuclear ribonucleoprotein C; Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilit [...] (306 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (434 aa)
MYH4Myosin-4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (830 aa)
ACTA1Actin, alpha skeletal muscle. (369 aa)
IGF2BP3Insulin like growth factor 2 mRNA binding protein 3. (527 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (393 aa)
METTL5Methyltransferase like 5. (209 aa)
ASH1LASH1 like histone lysine methyltransferase. (2966 aa)
ENSOCUP00000012913Oryctolagus cuniculus heterogeneous nuclear ribonucleoprotein C (HNRNPC), mRNA. (306 aa)
YTHDC1YTH domain containing 1. (655 aa)
VIRMAVir like m6A methyltransferase associated. (1811 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
MYH1Myosin-4; Muscle contraction. (1938 aa)
CTLA4Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. (223 aa)
METTL16U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (562 aa)
PRRC2AProline rich coiled-coil 2A. (2153 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
ZC3H13Zinc finger CCCH-type containing 13. (1682 aa)
MYH7Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
HNRNPA2B1Heterogeneous nuclear ribonucleoprotein A2/B1. (352 aa)
RBM15BSPOC domain-containing protein. (314 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (652 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
SPOPSpeckle type BTB/POZ protein. (407 aa)
FTOFTO_NTD domain-containing protein. (504 aa)
HNRNPA2B1-2Heterogeneous nuclear ribonucleoprotein A2/B1. (340 aa)
IGF2BP2Insulin like growth factor 2 mRNA binding protein 2. (681 aa)
TRIM44Tripartite motif containing 44. (537 aa)
WTAPWT1 associated protein. (448 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (602 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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